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产品信息
PEP-1424
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 16 amino acid peptide near the carboxy terminus of human PHOX2A.
PEP-1424 can be used as a blocking peptide with polyclonal antibody PA5-34381.
靶标信息
PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: aristaless homeobox homolog; Aristaless homeobox protein homolog; arix homeodomain protein; ARIX1 homeodomain protein; Paired mesoderm homeobox protein 2A; Paired-like homeobox 2A
基因别名: ARIX; CFEOM2; FEOM2; NCAM2; PHOX2A; PMX2A
UniProt ID: (Human) O14813
Entrez Gene ID: (Human) 401
分子生物学功能:
homeodomain transcription factor
noradrenergic neuron differentiation
transcription, DNA-templated
somatic motor neuron differentiation
oculomotor nerve formation
trochlear nerve formation
locus ceruleus development
midbrain development
regulation of respiratory gaseous exchange
positive regulation of transcription from RNA polymerase II promoter
sympathetic nervous system development
dopaminergic neuron differentiation
