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产品信息
PEP-1384
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 14 amino acids near the center of human PIWI-L2.
PEP-1384 can be used as a blocking peptide with polyclonal antibody PA5-34341.
靶标信息
The piwi gene of Drosophila belongs to a novel class of evolutionarily conserved genes (the piwi or Argonaute family). The Piwi family is required for germ and stem cell development in invertebrates, and two Piwi members, MIWI and MILI (Miwi like, Piwil2, Piwi-like protein 2), are essential for spermatogenesis in mouse. MIWI and MILI partner with Piwi-interacting RNAs (piRNAs) which are 26-31 nucleotides in length clearly distinct from the 21-23 nucleotides of microRNAs (miRNAs) or short interfering RNAs (siRNAs). A search for murine small RNAs that might program Piwi proteins for transposon suppression revealed developmentally regulated piRNA loci, some of which resemble transposon master control loci of Drosophila. MILI might be programmed by distinct piRNA populations at different stages of germ cell development, suggesting MILI plays an important role in meiotic prophase progression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 80kDa PIWIL2 short isoform; Cancer/testis antigen 80; CT80; Miwi like; PIWI-L2; piwi-like 2; Piwi-like protein 2; piwi-like RNA-mediated gene silencing 2; piwil2-like protein; testicular tissue protein Li 141
基因别名: CT80; HILI; mili; PIWIL1L; PIWIL2
UniProt ID: (Human) Q8TC59
Entrez Gene ID: (Human) 55124
分子生物学功能:
translation initiation factor
RNA 5'-end processing
multicellular organism development
spermatogenesis
germ-line stem cell population maintenance
gene silencing by RNA
piRNA metabolic process
DNA methylation involved in gamete generation
positive regulation of translation
oogenesis
meiotic cell cycle
positive regulation of meiosis I
positive regulation of histone H3-K14 acetylation
positive regulation of histone H3-K9 acetylation
