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产品信息
PEP-0974
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 14 amino acids near the carboxy terminus of human RHBDD1.
PEP-0974 can be used as a blocking peptide with polyclonal antibody PA5-20860.
靶标信息
The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD1 is highly expressed in the testis and is involved in the cleavage of BIK, a proapoptotic member of the Bcl-2 family. Overexpression or suppression by RNAi of RHBDD1 in 293 cells will reduce or enhance BIK-mediated apoptosis, respectively, demonstrating that RHBDD1 modulates BIK-mediated apoptotic activity. In GC-1 cells, a spermatogonia cell line that can differentiate into spermatids within the seminiferous tubules, suppression of RHBDD1 expression by RNAi caused the cells to lose the ability to survive and differentiate in mouse seminiferous tubules, suggesting that RHBDD1 may be associated with mammalian spermatogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Rhomboid domain-containing protein 1; Rhomboid-like protein 4; Rhomboid-related protein 4; RRP4
基因别名: HSD-50; HSD50; RHBDD1; RHBDL4; RRP4
UniProt ID: (Human) Q8TEB9
Entrez Gene ID: (Human) 84236
分子生物学功能:
serine protease
apoptotic process
positive regulation of protein processing
membrane protein intracellular domain proteolysis
cellular response to unfolded protein
cellular response to UV
ERAD pathway
negative regulation of apoptotic process
post-translational protein modification
spermatid differentiation
membrane protein proteolysis involved in retrograde protein transport, ER to cytosol
regulation of male germ cell proliferation
