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产品信息
PEP-0595
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 17 amino acids near the amino terminus of human Rim3.
PEP-0595 can be used as a blocking peptide with polyclonal antibody PA5-20475.
靶标信息
Rab3-interacting molecules (RIMs) are synaptic proteins are synaptic proteins necessary for neural transmission and plasticity. While both Rim1 and Rim 2 are thought to be effector proteins for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner, less is known of Rim3. Expression of Rim3 in PC12 cells induced a significant increase in calcium-triggered exocytosis, with no appreciable change in the baseline release, suggesting that it plays a role in the regulation of exocytosis. Rim3 protein localizes primarily to neuronal dendrites and the postsynaptic densities, as opposed to Rim1 which is found in presynapse locations, indicating that Rim3 may contribute to synapse transmission and plasticity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Nim3; Rab-3 interacting molecule 3; Rab-3-interacting molecule 3; Regulating synaptic membrane exocytosis protein 3; RIM 3; RIM3 gamma; RP4-739H11.2
基因别名: KIAA0237; NIM3; RIM3; RIMS3
UniProt ID: (Human) Q9UJD0
Entrez Gene ID: (Human) 9783
分子生物学功能:
membrane traffic protein
