Invitrogen

Human SATB1 Synthetic Peptide

产品信息

PEP-0655

应用	建议稀释比	已发表文章
对照试剂 (Ctrl)	Assay-dependent	-
阻断反应 (BLOCK)	Assay-dependent	-

产品规格
种属反应	Human
宿主/亚型	Not Applicable
分类	Synthetic
类型	Peptide
偶联物	Unconjugated
形式	Liquid
浓度	200 µg/mL
纯化类型	purified
保存液	PBS, pH 7.2, with 0.1% BSA
内含物	0.02% sodium azide
保存条件	-20°C

产品详细信息

This peptide corresponds to 18 amino acids near the amino terminus of human SATB1.

PEP-0655 can be used as a blocking peptide with polyclonal antibody PA5-20535.

靶标信息

SATB1 (DNA-binding protein SATB1) is a crucial silencing factor that contributes to the initiation of X inactiviation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. SATB1 binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence, and at nuclear matrix- or scaffold-associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB1 is also a transcriptonal repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner by binding to matrix attachment regions of DNA and inducing a local chromatin-loop remodeling. SATB1 modulates the genes that are essential in the maturatio of the immune T-cell CD8SP from thymocytes. Alu-like motifs and SATB1-binding sites provide an unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL1 and IL2RA in T-cells by binding to the same domain as HDAC1.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DNA-binding protein SATB1; special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA); Special AT-rich sequence-binding protein 1

基因别名: SATB1

UniProt ID: (Human) Q01826

Entrez Gene ID: (Human) 6304

分子生物学功能: helix-turn-helix transcription factor DNA-binding transcription factor Lambda repressor-like transcription factor gene-specific transcriptional regulator

功能

negative regulation of transcription from RNA polymerase II promoter chromatin organization chromatin remodeling transcription, DNA-templated cellular component disassembly involved in execution phase of apoptosis epidermis development viral process histone methylation CD4-positive, alpha-beta T cell differentiation CD8-positive, alpha-beta T cell differentiation activated T cell proliferation reflex

参与通路

RNA polymerase II regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding chromatin binding double-stranded DNA binding protein binding

Human SATB1 Synthetic Peptide

产品信息

PEP-0655

对照试剂 (Ctrl)

阻断反应 (BLOCK)

种属反应

宿主/亚型

分类

类型

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

产品详细信息

靶标信息

篇参考文献 (0)

生物信息学

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