Invitrogen

Human SATB2 Synthetic Peptide

产品信息

PEP-0653

应用	建议稀释比	已发表文章
对照试剂 (Ctrl)	Assay-dependent	-
阻断反应 (BLOCK)	Assay-dependent	-

产品规格
种属反应	Human
宿主/亚型	Not Applicable
分类	Synthetic
类型	Peptide
偶联物	Unconjugated
形式	Liquid
浓度	200 µg/mL
纯化类型	purified
保存液	PBS, pH 7.2, with 0.1% BSA
内含物	0.02% sodium azide
保存条件	-20°C

产品详细信息

This peptide corresponds to 14 amino acids near the carboxy terminus of human SATB2.

PEP-0653 can be used as a blocking peptide with polyclonal antibody PA5-20533.

靶标信息

DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression. It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex. Mutations in the gene are associate with cleft palate isolated (CPI).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DNA-binding protein SATB2; FLJ21474; FLJ32076; MGC119474; MGC119477; SATB family member 2; Special AT-rich sequence-binding protein 2

基因别名: GLSS; KIAA1034; SATB2

UniProt ID: (Human) Q9UPW6

Entrez Gene ID: (Human) 23314

分子生物学功能: helix-turn-helix transcription factor DNA-binding transcription factor Lambda repressor-like transcription factor gene-specific transcriptional regulator

功能

negative regulation of transcription from RNA polymerase II promoter neuron migration osteoblast development chromatin remodeling transcription, DNA-templated regulation of transcription from RNA polymerase II promoter embryonic pattern specification covalent chromatin modification commitment of neuronal cell to specific neuron type in forebrain positive regulation of transcription from RNA polymerase II promoter embryonic skeletal system morphogenesis cartilage development palate development cellular response to organic substance

参与通路

chromatin binding protein binding sequence-specific DNA binding

Human SATB2 Synthetic Peptide

产品信息

PEP-0653

对照试剂 (Ctrl)

阻断反应 (BLOCK)

种属反应

宿主/亚型

分类

类型

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

产品详细信息

靶标信息

篇参考文献 (0)

生物信息学

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