Invitrogen

Human SOCS1 Synthetic Peptide

产品信息

PEP-0341

应用	建议稀释比	已发表文章
对照试剂 (Ctrl)	Assay-dependent	-
阻断反应 (BLOCK)	Assay-dependent	-

产品规格
种属反应	Human
宿主/亚型	Not Applicable
分类	Synthetic
类型	Peptide
偶联物	Unconjugated
形式	Liquid
浓度	200 µg/mL
纯化类型	purified
保存液	PBS, pH 7.2, with 0.1% BSA
内含物	0.02% sodium azide
保存条件	-20°C

产品详细信息

This peptide corresponds to 15 amino acids near the carboxy terminus of human SOCS1.

PEP-0341 can be used as a blocking peptide with polyclonal antibody PA5-20228.

靶标信息

The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: cytokine-inducible SH2 protein 1; JAB; JAK binding protein; JAK-binding protein; SOCS-1; SSI-1; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1; Tec-interacting protein 3; TIP-3

基因别名: CIS1; CISH1; JAB; SOCS-1; SOCS1; SSI-1; SSI1; TIP3

UniProt ID: (Human) O15524

Entrez Gene ID: (Human) 8651

分子生物学功能: kinase modulator

功能

regulation of protein phosphorylation negative regulation of protein kinase activity JAK-STAT cascade regulation of activation of JAK2 kinase activity protein ubiquitination cytokine-mediated signaling pathway organ regeneration response to estradiol response to lipopolysaccharide response to progesterone regulation of growth response to drug negative regulation of tyrosine phosphorylation of Stat1 protein negative regulation of tyrosine phosphorylation of Stat3 protein response to peptide hormone fat cell differentiation negative regulation of JAK-STAT cascade negative regulation of insulin receptor signaling pathway regulation of cytokine secretion regulation of interferon-gamma-mediated signaling pathway cellular response to amino acid stimulus

参与通路

protein kinase inhibitor activity insulin-like growth factor receptor binding protein binding kinase inhibitor activity protein kinase binding

Human SOCS1 Synthetic Peptide

产品信息

PEP-0341

对照试剂 (Ctrl)

阻断反应 (BLOCK)

种属反应

宿主/亚型

分类

类型

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

产品详细信息

靶标信息

篇参考文献 (0)

生物信息学

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