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产品信息
PEP-0488
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 24 amino acids near the carboxy terminus of human STIM1.
PEP-0488 can be used as a blocking peptide with polyclonal antibody PA5-20371.
靶标信息
STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: STIM1L; Stromal interaction molecule 1
基因别名: D11S4896E; GOK; IMD10; STIM1; STRMK; TAM; TAM1
UniProt ID: (Human) Q13586
Entrez Gene ID: (Human) 6786
