Invitrogen

Human TANK Synthetic Peptide

产品信息

PEP-0385

应用	建议稀释比	已发表文章
对照试剂 (Ctrl)	Assay-dependent	-
阻断反应 (BLOCK)	Assay-dependent	-

产品规格
种属反应	Human
宿主/亚型	Not Applicable
分类	Synthetic
类型	Peptide
偶联物	Unconjugated
形式	Liquid
浓度	200 µg/mL
纯化类型	purified
保存液	PBS, pH 7.2, with 0.1% BSA
内含物	0.02% sodium azide
保存条件	-20°C

产品详细信息

This peptide corresponds to 14 amino acids near the carboxy terminus of human TANK.

PEP-0385 can be used as a blocking peptide with polyclonal antibody PA5-20270.

靶标信息

TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappa-B. This activation of NF-kappa-B occurs through an association with the kinases IKK-iota and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the Ikappa-B complex. This suggests that in addition to the possibility that TBK1 and IKK-iota activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-kappa-B proteins. At least two isoforms of TANK are known to exist.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: I-TRAF; OTTHUMP00000200694; OTTHUMP00000200695; OTTHUMP00000200696; OTTHUMP00000200698; OTTHUMP00000200700; OTTHUMP00000200703; OTTHUMP00000200704; TRAF family member-associated NF-kappa-B activator; TRAF family member-associated NFKB activator; TRAF-interacting protein

基因别名: I-TRAF; ITRAF; TANK; TRAF2

UniProt ID: (Human) Q92844

Entrez Gene ID: (Human) 10010

功能

proteolysis cellular response to DNA damage stimulus signal transduction I-kappaB kinase/NF-kappaB signaling TRIF-dependent toll-like receptor signaling pathway negative regulation of I-kappaB kinase/NF-kappaB signaling cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to ionizing radiation positive regulation of protein deubiquitination positive regulation of ubiquitin-specific protease activity

参与通路

thiol-dependent ubiquitin-specific protease activity protein binding ubiquitin protein ligase binding deubiquitinase activator activity metal ion binding

Human TANK Synthetic Peptide

产品信息

PEP-0385

对照试剂 (Ctrl)

阻断反应 (BLOCK)

种属反应

宿主/亚型

分类

类型

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

产品详细信息

靶标信息

篇参考文献 (0)

生物信息学

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