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产品信息
PEP-0179
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 13 amino acids near the carboxy terminus of human TIRP.
PEP-0179 can be used as a blocking peptide with polyclonal antibody PA5-20060.
靶标信息
TRAM, or TRIF-related adaptor molecule (TICAM2), plays an essential role in the MyD88-independent signaling of TLR4. The functional absence of TRAM in vascular endothelial cells restricts TLR4 signaling to MyD88-dependent pathway. Overexpression of TRAM cDNA in endothelial cells reconstituted LPS-induced Trif-dependent NF-kB activation and cxcl10 promoter activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cytoplasmic adaptor; MyD88-4; NF-kappa-B-activating protein 502; Putative NF-kappa-B-activating protein 502; TAG; TICAM-2; TIR domain-containing adapter molecule 2; toll-like receptor adaptor molecule 2; Toll-like receptor adaptor protein 3; toll/interleukin-1 receptor (TIR) domain-containing adapter protein; Toll/interleukin-1 receptor domain-containing protein; TRIF-related adapter molecule; TRIF-related adaptor molecule
基因别名: MyD88-4; TICAM-2; TICAM2; TIRAP3; TIRP; TRAM
UniProt ID: (Human) Q86XR7
Entrez Gene ID: (Human) 353376
分子生物学功能:
vesicle coat protein
MyD88-independent toll-like receptor signaling pathway
inflammatory response
I-kappaB kinase/NF-kappaB signaling
positive regulation of interferon-gamma production
positive regulation of interleukin-6 production
negative regulation of MyD88-independent toll-like receptor signaling pathway
toll-like receptor 4 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
TRIF-dependent toll-like receptor signaling pathway
TRAM-dependent toll-like receptor 4 signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
necroptotic process
response to interleukin-12
cellular response to lipopolysaccharide
positive regulation of chemokine (C-C motif) ligand 5 production
apoptotic signaling pathway
positive regulation of interleukin-18-mediated signaling pathway
