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产品信息
PEP-0317
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 15 amino acids near the amino terminus of human TLR6.
PEP-0317 can be used as a blocking peptide with polyclonal antibody PA5-20187.
靶标信息
TLR6 (Toll-like receptor 6) is a member of the toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved and share structural and functional similarities. TLRs recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR6 functionally interacts with TLR2 to mediate cellular response to bacterial lipoproteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD antigen 286; CD286; Toll-like receptor 6
基因别名: CD286; TLR6
UniProt ID: (Human) Q9Y2C9
Entrez Gene ID: (Human) 10333
toll-like receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
immune response
signal transduction
activation of NF-kappaB-inducing kinase activity
toll-like receptor 6 signaling pathway
toll-like receptor TLR6:TLR2 signaling pathway
T-helper 1 type immune response
detection of diacyl bacterial lipopeptide
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of JUN kinase activity
innate immune response
positive regulation of interleukin-6 biosynthetic process
interleukin-1 beta secretion
regulation of cytokine secretion
cellular response to diacyl bacterial lipopeptide
positive regulation of NLRP3 inflammasome complex assembly
