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产品信息
PEP-0330
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 16 amino acids near the carboxy terminus of human TLR9.
PEP-0330 can be used as a blocking peptide with polyclonal antibody PA5-20202.
靶标信息
The protein encoded by this gene is a member of the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD289; Toll-like receptor 9
基因别名: CD289; TLR9; UNQ5798/PRO19605
UniProt ID: (Human) Q9NR96
Entrez Gene ID: (Human) 54106
toll-like receptor signaling pathway
response to molecule of bacterial origin
MyD88-dependent toll-like receptor signaling pathway
inflammatory response
I-kappaB phosphorylation
axonogenesis
positive regulation of gene expression
maintenance of gastrointestinal epithelium
negative regulation of NF-kappaB transcription factor activity
tumor necrosis factor production
negative regulation of interleukin-6 production
negative regulation of interleukin-8 production
positive regulation of chemokine production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-beta production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-18 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
negative regulation of toll-like receptor signaling pathway
positive regulation of toll-like receptor signaling pathway
toll-like receptor 9 signaling pathway
phosphatidylinositol-3-phosphate biosynthetic process
positive regulation of NF-kappaB import into nucleus
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of JUN kinase activity
positive regulation of interferon-gamma biosynthetic process
innate immune response
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
regulation of cytokine secretion
positive regulation of inflammatory response
defense response to Gram-negative bacterium
positive regulation of NF-kappaB transcription factor activity
positive regulation of nitric-oxide synthase biosynthetic process
negative regulation of calcium-transporting ATPase activity
