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产品信息
PEP-0436
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 18 amino acids near the center of human TMP21
PEP-0436 can be used as a blocking peptide with polyclonal antibody PA5-20316.
靶标信息
TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the -gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the -gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased -gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate -gamma-secretase activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 21 kDa transmembrane trafficking protein; 21 kDa transmembrane-trafficking protein; p23; p24 family protein delta-1; p24delta; p24delta1; Protein TMED10; S31I125; S31III125; testicular tissue protein Li 206; Tmp-21-I; Transmembrane emp24 domain-containing protein 10; transmembrane emp24-like trafficking protein 10; Transmembrane protein Tmp21
基因别名: p23; P24(DELTA); p24d1; S31I125; S31III125; TMED10; Tmp-21-I; TMP21
UniProt ID: (Human) P49755
Entrez Gene ID: (Human) 10972
分子生物学功能:
vesicle coat protein
kidney development
intracellular protein transport
ER to Golgi vesicle-mediated transport
retrograde vesicle-mediated transport, Golgi to ER
Golgi organization
cargo loading into vesicle
COPI-coated vesicle budding
response to alkaloid
regulated exocytosis
vesicle targeting, to, from or within Golgi
COPI coating of Golgi vesicle
COPII vesicle coating
protein oligomerization
regulation of beta-amyloid formation
