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产品信息
PEP-0989
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
对照试剂 (Ctrl) |
Assay-dependent | - |
阻断反应 (BLOCK) |
Assay-dependent | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Not Applicable |
分类 |
Synthetic |
类型 |
Peptide |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
200 µg/mL |
纯化类型 |
purified |
保存液 |
PBS, pH 7.2, with 0.1% BSA |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
产品详细信息
This peptide corresponds to 15 amino acids near the center of human VLK.
PEP-0989 can be used as a blocking peptide with polyclonal antibody PA5-20875.
靶标信息
VLK was identified as a novel protein kinase that was induced after the differentiation of cultured embryonic stem cells into mesendoderm. It has no homologs in invertebrates, but is highly conserved in vertebrate species although it does not belong to any known protein kinase groups. VLK is initially expressed in E-cadherin-positive anterior visceral endoderm and mesendoderm, but its expression is later confined to E-cadherin-negative mesenchyme. It is enriched in the Golgi apparatus and is thought to regulate the rate of protein export from the Golgi. Targeted disruption of VLK in mice leads to a defect in lung development and neonatal lethality. It has been suggested that mutations in VLK may be associated with the allergic condition atopy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Extracellular tyrosine-protein kinase PKDCC; protein kinase domain containing, cytoplasmic homolog; Protein kinase domain-containing protein, cytoplasmic; Protein kinase-like protein SgK493; Sugen kinase 493; Vertebrate lonesome kinase
基因别名: PKDCC; SGK493; VLK
UniProt ID: (Human) Q504Y2
Entrez Gene ID: (Human) 91461
skeletal system development
protein transport
peptidyl-tyrosine phosphorylation
cell differentiation
bone mineralization
positive regulation of bone mineralization
positive regulation of chondrocyte differentiation
limb morphogenesis
multicellular organism growth
negative regulation of Golgi to plasma membrane protein transport
lung alveolus development
embryonic digestive tract development
palate development
