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          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Huntingtin Antibodies

          Invitrogen

          Huntingtin Polyclonal Antibody

          高级验证
          查看其他36个Huntingtin抗体

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          说明书
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          问题与答案
          技术支持
          说明书
          实验方案
          问题与答案
          技术支持

          Cite Huntingtin Polyclonal Antibody

          • 抗体检测数据 (9)
          • 高级验证 (2)
          Huntingtin Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          Huntingtin Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          图: 1 / 11

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          Huntingtin Antibody (PA5-85721) in ICC/IF

          Immunofluorescence analysis of Huntingtin was performed using 70% confluent log phase SH-SY5Y cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Huntingtin Polyclonal Antibody (Product # PA5-85721) at 1:100 dilution in 0.1% BSA, incubated at 4 degree... View More {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
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          查看产品

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          Huntingtin Antibody in Immunocytochemistry (ICC/IF)
          Huntingtin Antibody in Immunocytochemistry (ICC/IF)
          Huntingtin Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Huntingtin Antibody in Western Blot (WB)
          Huntingtin Antibody in Western Blot (WB)
          Huntingtin Antibody in Western Blot (WB)
          Huntingtin Antibody in Western Blot (WB)
          Huntingtin Antibody in Western Blot (WB)
          Huntingtin Antibody in Western Blot (WB)
          Huntingtin Antibody
          Huntingtin Antibody

          产品信息

          PA5-85721

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1:500-1:3,000
          -

          免疫组化(石蜡) (IHC (P))

          1:100-1:1,000
          -

          免疫细胞化学 (ICC/IF)

          1:100-1:1,000
          -

          免疫沉淀 (IP)

          Assay-dependent
          -
          产品规格

          种属反应

          Human, Mouse, Rat

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human Huntingtin. The exact sequence is proprietary.
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          1.4 mg/mL

          纯化类型

          Antigen affinity chromatography

          保存液

          PBS, pH 7, with 20% glycerol

          内含物

          0.025% ProClin 300

          保存条件

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2792860

          产品详细信息

          Keep as concentrated solution.

          Predicted reactivity: Mouse (100%), Rat (100%), Pig (100%), Sheep (100%).

          Positive Control: U87-MG.

          Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

          靶标信息

          Huntingtin is a disease gene linked to Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. HD is a mid-life onset autosomal dominant neurodegenerative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years.The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

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          引用该产品

          生物信息学

          蛋白别名: HD protein; HD protein homolog; Huntingtin; huntingtin (Huntington disease); Huntington disease gene homolog; Huntington disease protein; huntington disease protein homolog

          查看更多 收起

          基因别名: AI256365; C430023I11Rik; HD; Hdh; HTT; IT15

          查看更多 收起

          UniProt ID: (Human) P42858

          查看更多 收起

          Entrez Gene ID: (Human) 3064, (Rat) 29424, (Mouse) 15194

          查看更多 收起

          功能
          p53 binding receptor binding protein binding profilin binding transcription factor binding dynactin binding identical protein binding ion channel binding dynein intermediate chain binding beta-tubulin binding diazepam binding
          参与通路
          urea cycle citrulline metabolic process establishment of mitotic spindle orientation protein import into nucleus mitochondrial transport ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER apoptotic process mitochondrion organization endoplasmic reticulum organization Golgi organization dopamine receptor signaling pathway spermatogenesis gastrulation central nervous system development brain development cell aging learning or memory learning grooming behavior locomotory behavior axo-dendritic transport associative learning determination of adult lifespan visual learning anatomical structure morphogenesis anterior/posterior pattern specification endosomal transport lactate biosynthetic process from pyruvate quinolinate biosynthetic process striatum development olfactory lobe development neural plate formation neurogenesis peptide hormone secretion insulin secretion positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity regulation of protein phosphatase type 2A activity social behavior hormone metabolic process negative regulation of apoptotic process negative regulation of neuron apoptotic process regulation of mitochondrial membrane permeability vesicle transport along microtubule regulation of synaptic plasticity paraxial mesoderm formation animal organ development neuron development mRNA transport neuron apoptotic process response to calcium ion regulation of mitochondrial membrane potential L-glutamate import iron ion homeostasis negative regulation of neuron death negative regulation of cysteine-type endopeptidase activity negative regulation of extrinsic apoptotic signaling pathway vocal learning positive regulation of cilium assembly embryo development
          It has to be done as per old AB suggested Products section.
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