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Invitrogen
I-Ak Monoclonal Antibody (14V.18), Biotin
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产品信息
MA5-17772
产品规格
种属反应
Mouse
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
14V.18
抗原
A.TL spleen
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Protein G
保存液
PBS with 4-5mg/mL BSA
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-17772 targets I-Ak in FACS applications and shows reactivity with Mouse samples.
The MA5-17772 immunogen is a.TL spleen.
靶标信息
MHC Class II (I-Ak) serves as a critical component of the immune system, facilitating the recognition and response to extracellular pathogens and foreign substances. Its primary role is to present peptides derived from extracellular proteins to T cells for immune recognition. MHC Class II (I-Ak) is composed of an alpha and beta chain, both of which contribute to the peptide-binding groove. The location of MHC Class II (I-Ak) is restricted to antigen-presenting cells, such as dendritic cells, macrophages, and B cells. These cells are responsible for capturing and processing antigens from the extracellular environment. MHC Class II (I-Ak) consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail. The extracellular domain is responsible for interacting with the antigenic peptides, while the transmembrane domain anchors the MHC Class II molecule to the cell membrane. The cytoplasmic tail plays a role in intracellular signaling events.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A alpha; H-2 class II histocompatibility antigen, A-B alpha chain; H-2 class II histocompatibility antigen, A-F alpha chain; H-2 class II histocompatibility antigen, A-K alpha chain; H-2 class II histocompatibility antigen, A-Q alpha chain; H-2 class II histocompatibility antigen, A-R alpha chain; H-2 class II histocompatibility antigen, A-S alpha chain; H-2 class II histocompatibility antigen, A-U alpha chain; histocompatibility 2, class II antigen A, alpha; IAalpha; major histocompatibility protein class II alpha chain; MHC class II antigen A alpha isoform-004; MHC-II I-A(d) alpha
基因别名: Aalpha; H-2Aa; H2-Aa; H2Aa; I-Aalpha; Ia-1; Ia1; IAalpha
UniProt ID: (Mouse) P14434
Entrez Gene ID: (Mouse) 14960
immune system process
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
immune response
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
response to interferon-gamma
negative regulation of T cell proliferation
positive regulation of T cell differentiation
antigen processing and presentation of peptide antigen
