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Invitrogen
I-Ap Monoclonal Antibody (7-16.17), PE
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产品信息
MA5-17770
产品规格
种属反应
Mouse
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
7-16.17
抗原
B10.p
偶联物
激发/发射光谱
565/576 nm
查看光谱
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Protein G
保存液
PBS with 4-5mg/mL BSA
内含物
0.02% sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-17770 targets I-Ap in FACS applications and shows reactivity with Mouse samples.
The MA5-17770 immunogen is b10.p.
靶标信息
MHC Class II (I-Ap) is a protein complex found on the surface of cells in vertebrates. Its main function is to present peptides derived from extracellular proteins to T cells for immune recognition. MHC Class II (I-Ap) is composed of an alpha and beta chain, both of which contribute to the peptide-binding groove. MHC Class II (I-Ap) is primarily restricted to antigen-presenting cells, including dendritic cells, macrophages, and B cells. These cells are responsible for capturing and processing antigens from the extracellular environment. Once the antigens are internalized, they are broken down into smaller peptides, which then bind to MHC Class II molecules within the endosomal compartments of these cells. MHC Class II (I-Ap) consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail. The extracellular domain is responsible for interacting with the antigenic peptides, while the transmembrane domain anchors the MHC Class II molecule to the cell membrane. The cytoplasmic tail plays a role in intracellular signaling events.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cell surface glycoprotein; H-2 class II histocompatibility antigen, I-E beta chain; I-E beta MHC class II; major histocompatibility complex H-2E beta chain; MHC class II IE-b; MHC H2-IE-beta cell surface glycoprotein
基因别名: H-2Eb; H2Eb; Ia-4; Ia4
Entrez Gene ID: (Mouse) 14969
