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Immunogen sequence: LHKQKDGTEF KSIYSLDKLY PESQGSDTAW RVPNGAKQAD SDIPLDRLTI SYCRSSGPGG QNVNKVNSKA EVRFHLATAE WIAEPVRQKI AITHKNKINR LGELILTSES SRYQFRNLAD CLQKIRDMIT EASQTPKEPT KEDVKLHRIR IENMNRERLR QKRIHSAVKT SRRVDMD; Positive Samples: Raji, HT-29, 293T, B-cell, Skov3, Mouse lung, Mouse kidney, Mouse brain; Cellular Location: Mitochondrion
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.
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仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 39S ribosomal protein L58, mitochondrial; Digestion substraction 1; DS-1; Immature colon carcinoma transcript 1 protein; Immature colon carcinoma transcript 1 protein homolog; Large ribosomal subunit protein mL62; MRP-L58; Peptidyl-tRNA hydrolase ICT1, mitochondrial
基因别名: 1110001A02Rik; 1110002E03Rik; DS-1; DS1; ICT1; MRP-L58; MRPL58
UniProt ID: (Mouse) Q8R035, (Human) Q14197
Entrez Gene ID: (Mouse) 68572, (Human) 3396
分子生物学功能: translation factor translation release factor translational protein