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Invitrogen
ID2 Polyclonal Antibody
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ID2 Antibody (PA5-79434) in WB
Western blot analysis of ID2 in, Lane 1: rat brain tissue lysates. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50 µg of sample under reducing conditions. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. The membrane was blocked with 5% Non-fat Milk/ TBS for 1. 5 hour at RT. The membrane was incubated with ID2 Polyclonal Antibody (Product # PA5-79434) at 0.5 μg/mL overnigh... View More
产品信息
PA5-79434
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human ID2 (86-120aa VSLHHQRPGQNQASRTPLTTLNTDISILSLQASEF).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: rat brain tissue.
靶标信息
The inhibitor of DNA binding 2 (ID2) protein is essential for promoting the development of a number of cell types including natural killer cell, erythroid precursors, as well as, CD8+ and CD4+ T-cell. A lack of ID2 promotes B-cell development. The chief role of this protein is to associate with ubiquitously-expressed E proteins, and other proteins of the basic helix-loop-helix (HLH) family, preventing them from binding to DNA and activating transcription. Activation of ID2 is critical for the development of the natural killer cell lineage.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bHLHb26; cell growth-inhibiting gene 8; Class B basic helix-loop-helix protein 26; DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID2; helix-loop-helix protein ID2; Inhibitor of differentiation 2; Inhibitor of DNA binding 2; Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; MGC26389; OTTHUMP00000140258; OTTHUMP00000200297
基因别名: Ac2-300; BHLHB26; GIG8; Id-2; ID2; ID2A; ID2H
UniProt ID: (Human) Q02363, (Rat) P41137
Entrez Gene ID: (Human) 3398, (Rat) 25587
negative regulation of transcription from RNA polymerase II promoter
metanephros development
natural killer cell differentiation
thigmotaxis
membranous septum morphogenesis
bundle of His development
transcription, DNA-templated
multicellular organism development
adult locomotory behavior
positive regulation of gene expression
negative regulation of gene expression
oligodendrocyte development
regulation of lipid metabolic process
olfactory bulb development
circadian regulation of gene expression
mammary gland epithelial cell proliferation
regulation of circadian rhythm
entrainment of circadian clock by photoperiod
enucleate erythrocyte differentiation
negative regulation of DNA binding
negative regulation of sequence-specific DNA binding transcription factor activity
locomotor rhythm
negative regulation of B cell differentiation
positive regulation of fat cell differentiation
positive regulation of erythrocyte differentiation
positive regulation of macrophage differentiation
negative regulation of neuron differentiation
negative regulation of osteoblast differentiation
positive regulation of blood pressure
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
cell maturation
Peyer's patch development
embryonic digestive tract morphogenesis
positive regulation of smooth muscle cell proliferation
neuron fate commitment
cell morphogenesis involved in neuron differentiation
positive regulation of astrocyte differentiation
negative regulation of oligodendrocyte differentiation
adipose tissue development
mammary gland alveolus development
epithelial cell differentiation involved in mammary gland alveolus development
endodermal digestive tract morphogenesis
positive regulation of cell cycle arrest
cellular response to lithium ion
positive regulation of transcription involved in G1/S transition of mitotic cell cycle
cellular senescence
regulation of G1/S transition of mitotic cell cycle
negative regulation of neural precursor cell proliferation
leukocyte differentiation
heart development
positive regulation of cell proliferation
entrainment of circadian clock
neuron differentiation
positive regulation of cell cycle
cell development
