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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
IGF2BP2 is a member of the IGF-II mRNA-binding protein (IMP) family. It recruits target transcripts to cytoplasmic protein-RNA complexes. The protein contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; IGF2 mRNA-binding protein 2; insulin-like growth factor 2 mRNA binding protein 2; Insulin-like growth factor 2 mRNA-binding protein 2; insulin-like growth factor 2, binding protein 2; VICKZ family member 2
基因别名: C330012H03Rik; IGF2BP2; IMP-2; IMP2; Neilsen; VICKZ2
UniProt ID: (Human) Q9Y6M1, (Mouse) Q5SF07
Entrez Gene ID: (Human) 10644, (Mouse) 319765
分子生物学功能:
RNA metabolism protein
