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Invitrogen
IGF2BP2 Recombinant Polyclonal Antibody (1HCLC)
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
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IGF2BP2 Antibody (712137) in ICC/IF
For immunofluorescence analysis, Hep G2 cells were fixed and permeabilized detection of endogenous IGF2BP2 using Anti-IGF2BP2 Recombinant Rabbit Polyclonal Antibody (Product # 712137, 1:100) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Nuclei (blue) were stained using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938), and Rhodamine Phalloidin (Product # R415, 1:300) was used for cytoskeletal F-actin (red) staining. Panel a-d) clearly ... View More
产品信息
712137
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Polyclonal
类型
Antibody
克隆号
1HCLC
抗原
Peptides corresponding to human IGF2BP2 [1) aa17-aa32 2) aa583-aa599]
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2762371
产品详细信息
This antibody is predicted to react with Monkey, Pig, Bovine.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
IGF2BP2 is a member of the IGF-II mRNA-binding protein (IMP) family. It recruits target transcripts to cytoplasmic protein-RNA complexes. The protein contains several four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Hepatocellular carcinoma autoantigen p62; IGF-II mRNA-binding protein 2; IGF2 mRNA-binding protein 2; insulin-like growth factor 2 mRNA binding protein 2; Insulin-like growth factor 2 mRNA-binding protein 2; VICKZ family member 2
基因别名: IGF2BP2; IMP-2; IMP2; VICKZ2
UniProt ID: (Human) Q9Y6M1
Entrez Gene ID: (Human) 10644
