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Abnova
IGFBP2 Polyclonal Antibody, MaxPab™
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产品信息
H00003485-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
IGFBP2 (NP_000588.2, 1 a.a. approximately 328 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5-1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MLPRVGCPAL PLPPPPLLPL LPLLLLLLGA SGGGGGARAE VLFRCPPCTP ERLAACGPPP VAPPAAVAAV AGGARMPCAE LVREPGCGCC SVCARLEGEA CGVYTPRCGQ GLRCYPHPGS ELPLQALVMG EGTCEKRRDA EYGASPEQVA DNGDDHSEGG LVENHVDSTM NMLGGGGSAG RKPLKSGMKE LAVFREKVTE QHRQMGKGGK HHLGLEEPKK LRPPPARTPC QQELDQVLER ISTMRLPDER GPLEHLYSLH IPNCDKHGLY NLKQCKMSLN GQRGECWCVN PNTGKLIQGA PTIRGDPECH LFYNEQQEAR GVHTQRMQ
靶标信息
IGFBP2 (insulin-like growth factor binding protein 2) is a member of the ISGBP family which bind various IGFs. IGFBP2 is overexpressed in a wide spectrum of cancers, including glioma, prostate cancer, synovial sarcoma, neuroblastoma, colon cancer, adrenocortical cancer, lung cancer, Wilms' tumor, and hepatoblastoma. The overexpression of IGFBP2 also correlates with the aggressiveness of some tumors. IGFBP2 activates the expression of matrix metalloprotease 2, which contributes to cell invasiveness.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: IBP-2; IGF binding protein 2; IGF-binding protein 2; IGFBP; Insulin like growth factor binding protein; insulin-like growth factor binding protein 2; insulin-like growth factor binding protein 2, 36kDa; Insulin-like growth factor-binding protein 2; OTTHUMP00000207753
基因别名: BP2; IBP2; IGF-BP53; IGFBP2
UniProt ID: (Human) P18065
Entrez Gene ID: (Human) 3485
regulation of cell growth
signal transduction
female pregnancy
aging
response to nutrient
response to mechanical stimulus
response to lithium ion
response to estradiol
response to retinoic acid
cellular response to hormone stimulus
positive regulation of activated T cell proliferation
response to drug
regulation of insulin-like growth factor receptor signaling pathway
response to estrogen
cellular protein metabolic process
response to glucocorticoid
negative regulation of canonical Wnt signaling pathway
