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GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: interferon-gamma-inducible GTPase Ifgga1 protein; Interferon-inducible GTPase 1
基因别名: 2900074L10Rik; AI046432; AW111922; Ifgga1; Iigp; Iigp1; Irga6
UniProt ID: (Mouse) Q9QZ85
Entrez Gene ID: (Mouse) 60440