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Leinco Technologies
IL-1 alpha Monoclonal Antibody (ALF-161), Functional Grade, In Vivo GOLD™
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产品信息
I-428-1MG
产品规格
种属反应
Mouse
宿主/亚型
Armenian hamster
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
ALF-161
抗原
Proprietary immunogen
偶联物
形式
Liquid
浓度
≥5.0 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.2-7.4
内含物
no preservative
保存条件
4°C short term, -80°C long term
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Specificity: Anti-Mouse IL-1alpha recognizes Mouse IL-1alpha. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Endotoxin Level: ≤ 1.0 EU/mg as determined by the LAL method. Purity: >95% by SDS Page; ≥95% monomer by analytical SEC.
Product Preparation: Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling: Functional grade preclinical antibodies may be stored sterile as received at 2-8 C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80 C. Avoid Repeated Freeze Thaw Cycles.
This antibody has been tested in the following applications: Western Blotting, Neutralization.
靶标信息
IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 alpha is coded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 beta. IL1A is located on the q arm on chromosome 2 at position 13. IL-1 alpha plays an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. IL-1 alpha activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. Further, IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury and induces apoptosis. The IL1A gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL1 alpha regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL-1 alpha can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-1 alpha are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CTLA8; IL 1 a; IL 1α; IL-1 alpha; IL17; IL1α; ILN; Interleukin; interleukin 17; Interleukin-1 alpha; Interleukin-17A; Interleukin1 alpha; RP23-160G19.8
基因别名: Il-1a; Il1a
UniProt ID: (Mouse) P01582
Entrez Gene ID: (Mouse) 16175
fever generation
connective tissue replacement involved in inflammatory response wound healing
inflammatory response
immune response
negative regulation of cell proliferation
positive regulation of vascular endothelial growth factor production
positive regulation of steroid biosynthetic process
cytokine-mediated signaling pathway
keratinization
positive regulation of prostaglandin secretion
positive regulation of interleukin-6 production
positive regulation of stress-activated MAPK cascade
cellular response to heat
ectopic germ cell programmed cell death
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of interleukin-2 biosynthetic process
positive regulation of angiogenesis
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
response to copper ion
positive regulation of cytokine secretion
positive regulation of cell division
regulation of sensory perception of pain
positive regulation of ERK1 and ERK2 cascade
extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of neutrophil migration
