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Leinco Technologies
IL-1 beta Monoclonal Antibody (B122), Functional Grade, In Vivo GOLD™
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产品信息
I-437-1MG
产品规格
种属反应
Mouse
宿主/亚型
Armenian hamster
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
B122
抗原
E. coli -expressed, recombinant mouse IL-1b
偶联物
Functional Grade
Functional Grade
Functional Grade
形式
Liquid
浓度
≥5.0 mg/mL
规格
1 mg
纯化类型
Protein A/G
保存液
PBS, pH 7.2-7.4
内含物
no preservative
保存条件
4°C short term, -80°C long term
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Specificity: Armenian Hamster Anti-Mouse IL-1beta (Clone B122) recognizes Mouse IL-1beta. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Endotoxin Level: ≤ 1.0 EU/mg as determined by the LAL method. Purity: >95% by SDS Page; ≥95% monomer by analytical SEC.
Product Preparation: Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling: Functional grade preclinical antibodies may be stored sterile as received at 2-8 C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80 C. Avoid Repeated Freeze Thaw Cycles.
This antibody has been tested in the following applications: Western Blotting, Neutralization, Immunoprecipitation.
靶标信息
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Hematopoietin 1 (H1); IFN beta inducing factor; il 1b; IL 1β; IL-1 beta; IL1 B; IL1β; ILN; Interleukin; Interleukin 1 beta precursor; Interleukin-1 beta; Interleukin-1b; Interleukin1 beta; LAF; Osteoclast activating factor (OAF); Pro interleukin 1 beta
基因别名: Il-1b; IL-1beta; Il1b
UniProt ID: (Mouse) P10749
Entrez Gene ID: (Mouse) 16176
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
activation of MAPK activity
fever generation
positive regulation of protein phosphorylation
inflammatory response
immune response
positive regulation of cytosolic calcium ion concentration
aging
memory
negative regulation of cell proliferation
response to carbohydrate
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
negative regulation of gene expression
negative regulation of glucose transport
positive regulation of cell death
negative regulation of glutamate secretion
cytokine-mediated signaling pathway
hyaluronan biosynthetic process
neutrophil chemotaxis
sequestering of triglyceride
positive regulation of fever generation
lipopolysaccharide-mediated signaling pathway
positive regulation of prostaglandin secretion
response to lipopolysaccharide
interleukin-1 beta production
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of interferon-gamma production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of stress-activated MAPK cascade
positive regulation of immature T cell proliferation in thymus
response to ATP
positive regulation of heterotypic cell-cell adhesion
social behavior
ectopic germ cell programmed cell death
positive regulation of myosin light chain kinase activity
cellular response to drug
positive regulation of T cell proliferation
positive regulation of NF-kappaB import into nucleus
positive regulation of apoptotic process
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of MAP kinase activity
protein kinase B signaling
positive regulation of JUN kinase activity
positive regulation of chemokine biosynthetic process
positive regulation of interleukin-2 biosynthetic process
positive regulation of interleukin-6 biosynthetic process
positive regulation of nitric oxide biosynthetic process
negative regulation of neuron differentiation
positive regulation of glial cell differentiation
positive regulation of angiogenesis
negative regulation of lipid metabolic process
positive regulation of mitotic nuclear division
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
negative regulation of insulin receptor signaling pathway
positive regulation of astrocyte differentiation
positive regulation of phagocytosis
negative regulation of neurogenesis
regulation of insulin secretion
leukocyte migration
negative regulation of lipid catabolic process
positive regulation of lipid catabolic process
positive regulation of membrane protein ectodomain proteolysis
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of cell division
positive regulation of calcidiol 1-monooxygenase activity
negative regulation of adiponectin secretion
positive regulation of ERK1 and ERK2 cascade
monocyte aggregation
cellular response to organic substance
cellular response to organic cyclic compound
positive regulation of monocyte chemotactic protein-1 production
positive regulation of neutrophil chemotaxis
extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of branching morphogenesis of a nerve
negative regulation of neural precursor cell proliferation
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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