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Proteintech
IL-12/IL-23 p40 Monoclonal Antibody (C17.8), CoraLite® Plus 647
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IL-12/IL-23 p40 Antibody (CL647-65097100T) in Flow
IFN-γ primed Balb/c Mouse peritoneal macrophages stimulated with LPS in the presence of a protein transport inhibitor were treated with fixation and permeabilization reagents and intracellularly stained with CoraLite 647-Rat IgG2a Isotype Control (left) or 5 µL CoraLite 647 Anti-Mouse IL-12/IL-23 p40 (Product # CL647-65097100T), Clone:C17.8) (right).
产品信息
CL647-65097100T
产品规格
宿主/亚型
Rat
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
C17.8
偶联物
激发/发射光谱
654/674 nm
形式
Liquid
浓度
5 µL/Test
保存条件
4°C, store in dark
运输条件
Wet ice
靶标信息
IL-12 is an interleukin produced by dendritic cells, neutrophils, macrophages and human lymphoblastoid cells as a result of antigenic stimulation. IL-12 is a heterodimeric cytokine encoded by IL-12A (p35) and IL-12B (p40). IL-23 is a heterodimeric cytokine that shares a subunit with IL-12 (IL-12B) along with an IL-23A (IL-23p19) subunit. Functionally, IL-12 increases the expression of vascular endothelial adhesion molecule-1 on the endothelium, directs leukocytes towards tumors and facilitates the ischemic-hemorrhagic necrosis of the tumor tissue. In comparison, IL-23 plays an important role in stimulating memory T-cells, and is required for the induction, expansion, maintenance and downstream effector functions of Th17 cells, which play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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