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产品信息
PA5-96053
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A recombinant fusion protein containing a sequence corresponding to amino acids 34-146 of human IL-13.
偶联物
Unconjugated
形式
Liquid
浓度
0.36 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2807855
产品详细信息
Immunogen sequence: PGPVPPSTAL RELIEELVNI TQNQKAPLCN GSMVWSINLT AGMYCAALES LINVSGCSAI EKTQRMLSGF CPHKVSAGQF SSLHVRDTKI EVAQFVKDLL LHLKKLFREG QFN
Positive Samples: Mouse pancreas
靶标信息
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and is involved in regulating inflammatory and immune responses. IL-13 down-regulates macrophage activity, thereby inhibiting the production of pro-inflammatory cytokines and chemokines, and is involved in allergen-induced asthma through mechanisms independent of IgE and eosinophils. IL-13 also regulates several stages of B cell maturation and differentiation, up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. Structurally, IL-13 closely resembles IL-3, IL-4, IL-5 and GM-CSF. The gene encoding IL-13, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with the IL-13 gene particularly close to IL4.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ALRH; ALRH antibody; BHR1; il 13; IL-13; ILN; Interleukin; Interleukin-13; Interleukin13; MGC116786; MGC116788; MGC116789; NC30 antibody; P600 antibody; T-cell activation protein P600
基因别名: IL-13; IL13; NC30; P600
UniProt ID: (Human) P35225, (Mouse) P20109, (Rat) P42203
Entrez Gene ID: (Human) 3596, (Mouse) 16163, (Rat) 116553
microglial cell activation
positive regulation of immunoglobulin production
inflammatory response
immune response
regulation of proton transport
positive regulation of B cell proliferation
positive regulation of connective tissue growth factor production
negative regulation of NAD(P)H oxidase activity
response to nicotine
positive regulation of tyrosine phosphorylation of Stat6 protein
positive regulation of macrophage activation
positive regulation of ion transport
positive regulation of mast cell degranulation
positive regulation of smooth muscle cell proliferation
positive regulation of protein secretion
positive regulation of release of sequestered calcium ion into cytosol
cellular response to cytokine stimulus
negative regulation of transforming growth factor beta production
negative regulation of neuron death
negative regulation of complement-dependent cytotoxicity
positive regulation of pancreatic stellate cell proliferation
negative regulation of endothelial cell apoptotic process
response to mechanical stimulus
response to lipopolysaccharide
response to ethanol
cellular response to mechanical stimulus
movement of cell or subcellular component
signal transduction
cell-cell signaling
negative regulation of lung ciliated cell differentiation
positive regulation of lung goblet cell differentiation
