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Invitrogen
IL-13/IL-22 (Donzakimig Biosimilar) Recombinant Human Monoclonal Antibody
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产品信息
MA562665
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ Ig Mix
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.7 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
IL-13 is an immunoregulatory cytokine produced mainly by activated Th2 cells. It plays a central role in allergic inflammation and asthma, acting through mechanisms that can be independent of IgE and eosinophils. IL-13 suppresses macrophage activity, reducing production of proinflammatory cytokines and chemokines. It also regulates B cell maturation and differentiation, upregulates CD23 and MHC class II expression, and promotes IgE class switching. Structurally related to IL-4, IL-5, IL-3, and GM-CSF, IL-13 is part of a cytokine gene cluster on chromosome 5q, located near the IL4 gene.
IL-22 is an alpha-helical cytokine of the IL-10/IFN family, produced primarily by activated T cells (including Th17 cells) and NK cells. The IL22 gene is located on chromosome 12q. IL-22 signals through a heterodimeric receptor composed of IL-22R1 and IL-10R2, activating pathways such as JAK-STAT, particularly STAT3. A soluble receptor, IL-22 binding protein (IL-22BP), can inhibit IL-22 signaling. Unlike many cytokines, IL-22 primarily targets nonimmune cells, including epithelial cells of the skin, gut, and respiratory tract, as well as hepatocytes and keratinocytes. It induces antimicrobial peptides, acute-phase proteins, and promotes tissue repair and wound healing. IL-22 is important for host defense against extracellular pathogens and is highly expressed in chronic inflammatory conditions, where it contributes to tissue inflammation and remodeling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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