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Invitrogen
IL-2 Polyclonal Antibody
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IL-2 Antibody (PA5-95173) in WB
Western blot analysis of IL-2 in Lane 1: rat thymus tissue lysate (40 µg), Lane 2: rat liver tissue lysate (40 µg), Lane 3: NRK whole cell lysate (40 µg), Lane 4: PC12 whole cell lysate (40 µg), Lane 5: RH35 whole cell lysate (40 µg). Samples were incubated with IL-2 polyclonal antibody (Product # PA5-95173).
产品信息
PA5-95173
应用
建议稀释比
已发表文章
产品规格
种属反应
Rat
已发表种属
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived rat IL-2 recombinant protein (Position: A21-Q155).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Rat IL-2 shares 66% and 80% amino acid (aa) sequence identity with human and mouse IL-2, respectively.
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Thymus Tissue, Rat Liver Tissue, NRK whole cell, PC12 whole cell, RH35 whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: H-IL-2; il 2; IL-2; ILN; Interleukin; Interleukin-2; Interleukin2; Involved in regulation of T cell clonal expansion; M-IL-2; T-cell growth factor; T-cell growth factor (TCGF); TCGF
基因别名: Il-2; Il2
UniProt ID: (Rat) P17108
Entrez Gene ID: (Rat) 116562
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
negative regulation of B cell apoptotic process
immune response
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
protein kinase C-activating G-protein coupled receptor signaling pathway
positive regulation of B cell proliferation
positive regulation of interferon-gamma production
positive regulation of interleukin-17 production
positive regulation of T cell proliferation
positive regulation of activated T cell proliferation
positive regulation of tyrosine phosphorylation of Stat5 protein
positive regulation of T cell differentiation
positive regulation of regulatory T cell differentiation
negative regulation of heart contraction
positive regulation of transcription from RNA polymerase II promoter
regulation of T cell homeostatic proliferation
positive regulation of isotype switching to IgG isotypes
negative regulation of lymphocyte proliferation
negative regulation of inflammatory response
positive regulation of immunoglobulin secretion
positive regulation of dendritic spine development
extrinsic apoptotic signaling pathway in absence of ligand
