Invitrogen

IL-22 Monoclonal Antibody (IL22JOP), Functional Grade, eBioscience™

IL-22 Antibody in Functional Assay (Functional)

图: 1 / 32

IL-22 Antibody (16-7222-82) in Functional

Neutralization of IL-22 Recombinant Protein activity as measured by IL-10 induction in COLO205 cells.

IL-22 Antibody in Immunohistochemistry (IHC)

IL-22 Antibody in Flow Cytometry, Neutralization (Flow, Neu)

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产品信息

16-7222-82

应用

建议稀释比

已发表文章

免疫组化 (IHC)

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流式细胞分析 (Flow)

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酶联免疫吸附实验 (ELISA)

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中和实验 (Neu)

Assay-Dependent

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功能检测 (Functional)

Assay-Dependent

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抑制试剂 (IA)

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其他PubMed (Misc)

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产品规格

种属反应

Human, Mouse, Rhesus monkey

已发表种属

Human, Mouse, Non-human primate, Rhesus monkey

宿主/亚型

Rat / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

IL22JOP

偶联物

Functional Grade Functional Grade Functional Grade

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2

内含物

no preservative

保存条件

4°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2016695

产品详细信息

Description: The monoclonal antibody IL22JOP reacts with and inhibits the bioactivity of human and mouse IL-22. IL-22 is a 20 kDa member of the IL-10 cytokine family that is secreted primarily by Th17 cells, NK cells, and other T cells. Compared to IL-6 or TGF beta, IL-23 can induce greater levels of IL-22 in in vitro-differentiated Th17 cells. This observation suggests that IL-22 may be secreted by more fully differentiated Th17 cells in vivo. Recently, it was demonstrated that IL-22 could protect hosts from bacterial infection of the lungs and gut. Moreover, it has been reported that anti-CD3/CD28-induced production of IL-22 by PBMCs was elevated significantly in asthma patients compared to control patients. Flow cytometric analysis also showed that the frequencies of IL-17+IL-22+ CD4 T cells were increased in PBMCs from patients with ankylosing spondylitis and rheumatoid arthritis.

IL22JOP is published to recognize rhesus IL-22.

Applications Reported: The monoclonal antibody IL22JOP reacts with and inhibits the bioactivity of human and mouse IL-22.

Applications Tested: The ND50 of IL22JOP, as determined by the inhibition of IL-10 induction in COLO205 cells by IL-22, is 10-40 ng/mL, in the presence of 0.2 ng/mL recombinant human or mouse IL-22. Neutralization dose will vary depending on assay method, cytokine concentration, and cell type.

Storage and handling: Use in a sterile environment.

Filtration: 0.2 µm post-manufacturing filtered.

Purity: Greater than 90%, as determined by SDS-PAGE.

Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.

Aggregation: Less than 10%, as determined by HPLC.

靶标信息

IL-22 also known as IL-10-related T-cell derived inducible factor, is an alpha helical cytokine and is considered a member of the IFN-IL-10 family, which includes IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and the type I and II interferons. IL-22 is produced mainly by activated T cells and NK cells. In humans, the IL-22 gene is located on the q arm of chromosome 12, and is structurally related to IL10. IL-22 acts by engaging the heterodimeric receptor complex consisting of primary receptor IL-22R1 and accessory receptor IL-10R2. IL-22R1 also binds IL-20 and IL-24; IL-10R2 also binds IL-10, IL-27, IL-28, and IL-29. Binding of IL-22 to its receptor complex induces signal transduction, particularly via the JAK-STAT pathway. In addition to the membrane-bound IL-22R1/IL-10R2 complex, a soluble single-chain IL-22 receptor termed IL-22BP has been found to antagonize IL-22 binding and signaling. IL-22 appears not to directly influence immune cells, and major targets of the cytokine appear to be nonimmune cells, such as cells of the skin, digestive and respiratory system, as well as hepatocytes, and keratinocytes. IL-22 has been described as an effector cytokine of the Th17 lineage. Along with IL-17A and IL-17F, IL-22 regulates genes associated with innate immunity of the skin. IL-17A, IL-17F and IL-22 are all co-expressed by Th17 cells, however, they are differentially regulated. The effects of IL-22 include induction of acute phase reactants and antimicrobial proteins, as well as increasing the mobility of keratinocytes. IL-22 is highly expressed during chronic inflammation, and found to activate intracellular kinases and transcription factors. IL-22 is critical for host defense against infections of extracellular pathogens, and promotes wound-healing responses. IL-22 is upregulated in activated T cells. IL-22 has been reported to mediate IL-23-induced acanthosis and dermal inflammation through activation of STAT3.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Expanded IL-22⁺ Group 3 Innate Lymphoid Cells and Role of Oxidized LDL-C in the Pathogenesis of Axial Spondyloarthritis with Dyslipidaemia.

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CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression.

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16-7222-82 was used in Flow Cytometry to eveal a role for IL-17 cytokines in mediating CD4-intrinsic immune resistance.

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Single-cell multi-omics analysis presents the landscape of peripheral blood T-cell subsets in human chronic prostatitis/chronic pelvic pain syndrome.

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Differential Activation of Unconventional T Cells, Including iNKT Cells, in Alcohol-Related Liver Disease.

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Chlamydia muridarum Alleviates Colitis via the IL-22/Occludin Signal Pathway.

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Chlamydia muridarum Alleviates Colitis via the IL-22/Occludin Signal Pathway.

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A Central Role for Lipocalin-2 in the Adaptation to Short-Bowel Syndrome Through Down-Regulation of IL22 in Mice.

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Interleukin-22 promotes T helper 1 (Th1)/Th17 immunity in chlamydial lung infection.

Molecular medicine (Cambridge, Mass.)

Peng Y,Gao X,Yang J,Shekhar S,Wang S,Fan Y,Zhao W,Yang X

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Thu Mar 20 00:00:00 UTC 2014

Interleukin-22 promotes T helper 1 (Th1)/Th17 immunity in chlamydial lung infection.

Molecular medicine (Cambridge, Mass.)

Peng Y,Gao X,Yang J,Shekhar S,Wang S,Fan Y,Zhao W,Yang X

Published figure using IL-22 monoclonal antibody (Product # 16-7222-82) in Flow Cytometry

Thu Mar 20 00:00:00 UTC 2014

Interleukin-22 promotes T helper 1 (Th1)/Th17 immunity in chlamydial lung infection.

Molecular medicine (Cambridge, Mass.)

Peng Y,Gao X,Yang J,Shekhar S,Wang S,Fan Y,Zhao W,Yang X

Published figure using IL-22 monoclonal antibody (Product # 16-7222-82) in Flow Cytometry

Thu Mar 20 00:00:00 UTC 2014

OMIP-022: Comprehensive assessment of antigen-specific human T-cell functionality and memory.

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Graves AJ,Padilla MG,Hokey DA

Published figure using IL-22 monoclonal antibody (Product # 16-7222-82) in Flow Cytometry

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The secretion of IL-22 from mucosal NKp44⁺ NK cells is associated with microbial translocation and virus infection in SIV/SHIV-infected Chinese macaques.

Journal of immunology research

Wang W,Wu F,Cong Z,Liu K,Qin C,Wei Q

16-7222 was used in Flow cytometry/Cell sorting to investigate the role of a novel subtype of innate lymphoid cells, the NKp44(+) NK cells, in SIV-induced microbial translocation.

Tue Dec 01 00:00:00 UTC 2015

Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation.

The Journal of experimental medicine

Mielke LA,Jones SA,Raverdeau M,Higgs R,Stefanska A,Groom JR,Misiak A,Dungan LS,Sutton CE,Streubel G,Bracken AP,Mills KH

16-7222 was used in in vitro experiments to provide novel insights into the molecular events controlling IL-22 transcription.

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Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease.

Clinical immunology (Orlando, Fla.)

Xu H,Feely SL,Wang X,Liu DX,Borda JT,Dufour J,Li W,Aye PP,Doxiadis GG,Khosla C,Veazey RS,Sestak K

16-7222 was used in Flow cytometry/Cell sorting to indicate that IL-17/22-producing cells play an important role in maintenance of intestinal mucosa in gluten-sensitive primates.

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Journal of immunology (Baltimore, Md. : 1950)

Canary LA,Vinton CL,Morcock DR,Pierce JB,Estes JD,Brenchley JM,Klatt NR

16-7222 was used in Flow cytometry/Cell sorting to determine whether pre-existing GI-associated mucosal damage affects the progression of AIDS following HIV infection.

Fri Mar 15 00:00:00 UTC 2013

生物信息学

蛋白别名: Cytokine Zcyto18; il 22; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; IL-22; IL-22a; IL-TIF; IL-TIF alpha; ILN; ILTIF alpha; Interleukin; interleukin 10-related T cell-derived inducible factor; Interleukin-22; Interleukin-22a; Interleukin22

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基因别名: EGK_03903; IL-21; IL-22; IL-22a; IL-D110; IL-TIF; IL22; Il22a; ILTIF; ILTIFa; TIFa; TIFIL-23; UNQ3099/PRO10096; ZCYTO18

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UniProt ID: (Human) Q9GZX6, (Mouse) Q9JJY9

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Entrez Gene ID: (Human) 50616, (Rhesus monkey) 718047, (Mouse) 50929

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功能

cytokine activity protein binding interleukin-22 receptor binding

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