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Proteintech
IL-22RA1 Polyclonal Antibody, CoraLite® Plus 488
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IL-22RA1 Antibody (CL488-13462) in Flow
1x10^6 HepG2 cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human IL-22RA1 (CL488-13462) (red), or 0.4 µg CoraLite® Plus 488-conjugated Rabbit IgG control Rabbit PolyAb (CL488-30000) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
产品信息
CL488-13462
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
IL-22RA1 fusion protein Ag4056
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: YVTKPPAPP NSLNVQRVLT FQPLRFIQEH VLIPVFDLSG PSSLAQPVQY SQIRVSGPRE PAGAPQRHSL SEITYLGQPD ISILQPSNVP PPQILSPLSY APNAAPEVGP PSYAPQVTPE AQFPFYAPQA ISKVQPSSYA PQATPDSWPP SYGVCMEGSG KDSPTGTLSS PKHLRPKGQL QKEPPAGSCM LGGLSLQEVT SLAMEESQEA KSLHQPLGIC TDRTSDPNVL HSGEEGTPQY LKGQLPLLSS VQIEGHPMSL PLQPPSRPCS PSDQGPSPWG LLESLVCPKD EAKSPAPETS DLEQPTELDS LFRGLALTVQ WES
靶标信息
A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CRF2-9; Cytokine receptor class-II member 9; Cytokine receptor family 2 member 9; il-22 receptor; IL-22 receptor subunit alpha-1; IL-22R-alpha-1; IL-22RA1; ILN; Interleukin; interleukin 22 receptor, alpha 1; interleukin-22 receptor alpha chain; Interleukin-22 receptor subunit alpha-1; ZcytoR11
基因别名: 9130219A07Rik; CRF2-9; ENSMUSG00000073746; IL-22R; IL22R; IL22R1; IL22RA1; RGD1559655
UniProt ID: (Human) Q8N6P7, (Mouse) Q80XZ4
Entrez Gene ID: (Human) 58985, (Mouse) 230828, (Rat) 362629
