Invitrogen

IL-23 p19 Monoclonal Antibody (320234)

Name: IL-23 p19 Monoclonal Antibody (320234)
Brand: Invitrogen
SKU: MA5-23793

查看其他33个IL-23 p19抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

产品信息

MA5-23793

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

酶联免疫吸附实验 (ELISA)

0.1-0.4 µg/mL (Detection), 2-8 µg/mL (Capture)

产品规格

种属反应

Mouse

宿主/亚型

Rat / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

320234

抗原

E. coli-derived recombinant mouse IL-23

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.5 mg/mL

纯化类型

Protein A/G

保存液

PBS with 5% trehalose

内含物

No Preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2605570

产品详细信息

This antibody recognizes an epitope in the p19 subunit. In ELISAs, this antibody does not cross-react with recombinant mouse (rm) IL-23 p19, rmIL-23 R, rmIL-12 R beta, rmIL-12 p35, recombinant human (rh) IL-23, rhIL-23 p19, recombinant rat IL-12, rmIL-12 p40, rmIL-12 p40 homodimer, or rmIL-12.

Reconstitute at 0.5 mg/mL in sterile PBS.

靶标信息

IL-23 is a heterodimeric cytokine composed of the p40 subunit of IL-12 disulfide-linked with a protein p19. p19, like p35 of IL-12, is biologically inactive by itself. IL-23 interacts with IL-12Rbeta1 and an additional, novel beta2-like receptor subunit with STAT4 binding domain, termed IL-23R. IL-23 is secreted by activated mouse and human dendritic cells. Biological activities of mouse IL-23 are distinct from those of mouse IL-12. Mouse IL-23 was found not to induce significant amounts of IFN-γ. Mouse IL-23 does induce strong proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Additionally, mouse IL-23 (but not IL-12) can activate mouse memory T cells to produce the proinflammatory cytokine IL-17. Human IL-23 has biological properties which are less distinct from human IL-12; human IL-23 induces proliferation of memory T cells and induces moderate levels of IFN-γ production by naive and memory T cells, as compared to IL-12.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: il 23; IL 23 A; Il-12b; Il-12p40; IL-23 subunit alpha; IL-23-A; IL-23p19; IL12B; Il12p40; il23; ILN; Interleukin; interleukin 12B; Interleukin-23 subunit alpha; Interleukin-23 subunit p19; MGC79388; p40; RP23-388G23.1

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基因别名: IL-23; Il23a; p19

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UniProt ID: (Mouse) Q9EQ14

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Entrez Gene ID: (Mouse) 83430

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功能

cytokine activity protein binding interleukin-23 receptor binding cytokine interleukin superfamily intercellular signal molecule

参与通路