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Invitrogen
IL-4 Monoclonal Antibody (24G2), Biotin
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产品信息
MM450DB
产品规格
种属反应
Mouse
已发表种属
Mouse
宿主/亚型
Rat
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
24G2
抗原
Recombinant mouse IL-4
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS with 4% BSA
内含物
proprietary Preservative
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
MM450DB targets IL-4 in ELISA, and WB applications and shows reactivity with mouse samples.
The MM450DB immunogen is recombinant mouse IL-4.
MM450DB detects IL-4 which has a predicted molecular weight of approximately 14 kDa.
The MM450DB mouse IL4 antibody (biotinylated conjugate of clone 24G2) has successfully been paired as the detection antibody in a sandwich ELISA with capture antibody MM450C (clone 1D11). Typical dilutions for sandwich ELISA include 1 µg/mL for coating and 0.125 - 0.25 µg/mL for detection.
Biotinylated antibody MM450DB (clone 24G2) and antibody MM450C (clone 1D11) have successfully been used in combination with recombinant mouse IL4 protein SMIL4 in ELISA applications.
This antibody is produced by injecting Rat IgG secreting hybridoma cells into the peritoneum of mice. The resulting ascites is collected from the mice and the antibody is purified.
靶标信息
Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BSF-1; H-IL-4; IGG1 induction factor; IL-4; ILN; Interleukin; Interleukin-4; Interleukin4; Lymphocyte stimulatory factor 1; M-IL-4; MGC79402
基因别名: BSF-1; Il-4; Il4
UniProt ID: (Mouse) P07750
Entrez Gene ID: (Mouse) 16189
microglial cell activation
positive regulation of protein phosphorylation
innate immune response in mucosa
positive regulation of defense response to virus by host
T-helper 1 cell lineage commitment
positive regulation of immunoglobulin production
negative regulation of acute inflammatory response
negative regulation of chronic inflammatory response
immune response
cholesterol metabolic process
positive regulation of cell proliferation
regulation of proton transport
negative regulation of epithelial cell migration
positive regulation of B cell proliferation
B cell costimulation
positive regulation of interleukin-10 production
positive regulation of interleukin-13 production
T-helper 2 cell cytokine production
positive regulation of T cell proliferation
positive regulation of activated T cell proliferation
B cell activation
positive regulation of tyrosine phosphorylation of Stat5 protein
defense response to protozoan
negative regulation of macrophage activation
positive regulation of mast cell degranulation
negative regulation of nitric oxide biosynthetic process
T-helper 2 cell differentiation
positive regulation of chemokine biosynthetic process
positive regulation of MHC class II biosynthetic process
positive regulation of T cell differentiation
negative regulation of osteoclast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of isotype switching to IgE isotypes
positive regulation of isotype switching to IgG isotypes
regulation of inflammatory response
positive regulation of peptidyl-tyrosine phosphorylation
regulation of immune response
negative regulation of T cell activation
positive regulation of B cell activation
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of mononuclear cell migration
dendritic cell differentiation
extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of myoblast fusion
negative regulation of complement-dependent cytotoxicity
negative regulation of T-helper 17 cell differentiation
negative regulation of endothelial cell apoptotic process
positive regulation of eosinophil chemotaxis
negative regulation of extrinsic apoptotic signaling pathway
