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Invitrogen
IL-4 Monoclonal Antibody (BVD6-24G2), Biotin, eBioscience™
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IL-4 Antibody (13-7042-81) in Flow
Staining of mouse splenocytes stimulated with ConA for 2 days, followed by IL-2 and IL-4 for 3 days, and restimulated with immobilized Anti-Mouse CD3 Functional Grade Purified (Product # 16-0031-82) and soluble Anti-Mouse CD28 Functional Grade Purified (Product # 16-0281-82) in the presence of Brefeldin A for 5 hours with Anti-Mouse CD4 PE (Product # 12-0041-82) and intracellularly stained with Anti-Mouse IL-4 FITC.
产品信息
13-7042-81
应用
建议稀释比
已发表文章
产品规格
已发表种属
C. elegans,
Mouse
宿主/亚型
Rat
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
BVD6-24G2
偶联物
形式
Liquid
浓度
0.5 mg/mL
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Wet ice
RRID
产品详细信息
Description: The BVD6-24G2 antibody reacts with mouse interleukin-4 (IL-4), a 14 kDa cytokine secreted by Th2 cells.
Applications Reported: The BVD6-24G2 antibody is used for detection of mouse IL-4 by ELISA.
Applications Tested: The BVD6-24G2 antibody has been tested as the detection antibody in a sandwich ELISA for analysis of mouse Interleukin-4 (IL-4) in combination with the purified 11B11 (14-7041) antibody for capture and recombinant mouse IL-4 (14-8041) as the standard. A suitable range of concentrations of this antibody for ELISA detection is 0.5-2 µg/mL. A standard curve consisting of doubling dilutions of the recombinant standard over the range of 500 pg/mL - 4 pg/mL should be included in each ELISA plate.
Filtration: 0.2 µm post-manufacturing filtered.
靶标信息
Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
