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Invitrogen
IL-6 Recombinant Rabbit Monoclonal Antibody (54H58L14)
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IL-6 Antibody (704978) in ICC/IF
Immunofluorescence analysis of IL-6 Recombinant Rabbit Monoclonal Antibody (54H58L14) (Product # 704978) on 70-80% HeLa cells treated with Human IL-1β (100 U/mL for 6 hrs) followed by Protein Transport Inhibitor (1X for 4 hrs). The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton X-100 for 15 minutes and blocked with 2% BSA for 1 hr at room temperature. The cells were stained with IL-6 Recombinant Rabbit Monoclonal Antibody (54H58L14) (Product # 704978, 1:200) in 0.1% BSA, incubated at 4 degree Celsi... View More
产品信息
704978
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
54H58L14
抗原
Protein corresponding to human IL-6 [aa29-aa212]
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
靶标信息
IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.
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生物信息学
蛋白别名: B-cell differentiation factor; B-cell stimulatory factor 2; BSF-2; CDF; CTL differentiation factor; H-IL-6; Hybridoma growth factor; hybridoma growth factor peptide; IFN-beta-2; IL-6; IL6; ILN; interferon 6 precursor; Interferon beta-2; Interleukin; interleukin 6; interleukin BSF-2; Interleukin-6; Interleukin6; M-IL-6; R-IL-6; unnamed protein product
基因别名: BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6; IL6
UniProt ID: (Human) P05231
Entrez Gene ID: (Human) 3569
neutrophil apoptotic process
germinal center B cell differentiation
hepatic immune response
neutrophil mediated immunity
monocyte chemotaxis
positive regulation of immunoglobulin production
positive regulation of acute inflammatory response
positive regulation of leukocyte chemotaxis
acute-phase response
inflammatory response
immune response
humoral immune response
JAK-STAT cascade
positive regulation of cell proliferation
negative regulation of cell proliferation
vascular endothelial growth factor production
regulation of vascular endothelial growth factor production
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
negative regulation of lipid storage
response to activity
cytokine-mediated signaling pathway
cell differentiation
platelet activation
endocrine pancreas development
neuron projection development
response to peptidoglycan
negative regulation of chemokine production
positive regulation of chemokine production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-10 production
positive regulation of interleukin-17 production
positive regulation of interleukin-21 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
negative regulation of collagen biosynthetic process
positive regulation of peptidyl-serine phosphorylation
maintenance of blood-brain barrier
positive regulation of T cell proliferation
glucose homeostasis
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of fat cell differentiation
positive regulation of osteoblast differentiation
positive regulation of translation
regulation of angiogenesis
negative regulation of bone resorption
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JAK-STAT cascade
positive regulation of smooth muscle cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of neurogenesis
regulation of insulin secretion
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
positive regulation of B cell activation
regulation of protein transport
positive regulation of lymphocyte activation
response to glucocorticoid
defense response to virus
positive regulation of glial cell proliferation
T follicular helper cell differentiation
regulation of astrocyte activation
neuron cellular homeostasis
glucagon secretion
regulation of glucagon secretion
interleukin-6-mediated signaling pathway
cellular response to hydrogen peroxide
cellular response to lipopolysaccharide
T-helper 17 cell lineage commitment
hepatocyte proliferation
positive regulation of extracellular matrix disassembly
inflammatory response to wounding
liver regeneration
receptor signaling pathway via STAT
cellular response to virus
regulation of neuroinflammatory response
positive regulation of neuroinflammatory response
positive regulation of cytokine production involved in inflammatory response
positive regulation of platelet aggregation
positive regulation of apoptotic DNA fragmentation
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
regulation of microglial cell activation
positive regulation of STAT cascade
positive regulation of leukocyte adhesion to vascular endothelial cell
positive regulation of T-helper 2 cell cytokine production
negative regulation of primary miRNA processing
negative regulation of interleukin-1-mediated signaling pathway
positive regulation of type B pancreatic cell apoptotic process
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