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Invitrogen
IL-7 Polyclonal Antibody
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IL-7 Antibody (PA5-46944) in Neu
Neutralization of IL-7 in PHA-activated human peripheral blood mononuclear cells (PBMC). Samples were incubated in IL-7 polyclonal antibody (Product # PA5-46944). Recombinant Mouse IL‚7 stimulates proliferation in PHA-activated human peripheral blood mononuclear cells (PBMC) in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse IL‚7 (1.5 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse IL‚7 Antigen Affinity-purified Polyclonal Antibody. The ND50 is typically 0.2-0.4 µg/mL.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-46944
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant mouse IL-7 Glu26-Ile154
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.2 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In sandwich ELISAs, approximately 20% cross-reactivity with recombinant rat IL-7 is observed, and less than 0.1% cross-reactivity with recombinant human IL-7 is observed. This antibody neutralizes the biological activity of recombinant mouse IL-7. This antibody will not neutralize the biological activity of recombinant human IL-7.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
Interleukin 7 (IL-7) is a hematopoietic cytokine that is constitutively produced by stromal cells from the bone marrow and thymus. IL-7 signals through the IL-7R to promote the differentiation of hematopoietic stem cells to lymphoid precursor cells, which give rise to T cells, B cells, and natural killer cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: H-IL-7; IL-7 receptor alpha chain; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; ILN; Interleukin; interleukin 7 receptor alpha chain; interleukin-7 receptor precursor; Interleukin7; M-IL-7; unnamed protein product
基因别名: A630026I06Rik; CD127; hlb368; Il-7; IL-7Ralpha
UniProt ID: (Mouse) P10168, (Mouse) P16872
Entrez Gene ID: (Mouse) 16196, (Mouse) 16197
positive regulation of cytokine-mediated signaling pathway
T cell lineage commitment
immune response
regulation of gene expression
positive regulation of gene expression
cytokine-mediated signaling pathway
cellular homeostasis
positive regulation of B cell proliferation
positive regulation of chemokine production
interleukin-7-mediated signaling pathway
negative regulation of catalytic activity
bone resorption
positive regulation of B cell differentiation
positive regulation of T cell differentiation
positive regulation of organ growth
homeostasis of number of cells within a tissue
regulation of peptidyl-tyrosine phosphorylation
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
cell morphogenesis
negative regulation of T cell mediated cytotoxicity
positive regulation of cell proliferation
regulation of cell size
hemopoiesis
T cell differentiation
positive regulation of T cell differentiation in thymus
B cell proliferation
positive regulation of JAK-STAT cascade
lymph node development
homeostasis of number of cells
defense response to Gram-positive bacterium
negative regulation of T cell apoptotic process
positive regulation of STAT cascade
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