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Invitrogen
IL36B Polyclonal Antibody
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IL36B Antibody (PA5-47066) in Neu
Neutralization of IL36B in human pre-adipocytes. Samples were incubated in IL36B polyclonal antibody (Product # PA5-47066). Recombinant Human IL‚36β/IL‚1F8 (aa 5-157) induces IL-8 secretion in human pre-adipocytes in a dose-dependent manner (orange line). IL-8 Secretion elicited by Recombinant Human IL‚36β/IL‚1F8 (aa 5-157) (20 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL‚36β/IL‚1F8 Antigen Affinity-purified Polyclonal Antibody. The ND50 is typically 50‚300 ng/mL.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-47066
产品规格
种属反应
Human
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant human IL-36 beta/IL-1F8 Met1-Glu157
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
0.2 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs, less than 5% cross-reactivity with recombinant human (rh) IL-1 beta and rhIL-1F6 is observed and less than 1% cross-reactivity with rhIL-1 alpha and rhIL-18 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
靶标信息
IL-36B is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL-36B is thought to activate the NF-kappaB pathway through IL-1 receptor family members IL-1RL2 and IL-1RAcP. Like the related proteins IL-36A and IL-36G, IL-36B requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown. The IL-36 cytokines have been suggested to amplify Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FIL1 eta; IL-1 eta; IL-1F8; IL-1H2; Interleukin; Interleukin-1 eta; Interleukin-1 family member 8; Interleukin-1 homolog 2; Interleukin-36 beta
基因别名: IL1F8; IL1H2; IL36B
Entrez Gene ID: (Human) 27177
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