Immunogen sequence: MRGDRGRGRG GRFGSRGGPG GGFRPFVPHI PFDFYLCEMA FPRVKPAPDE TSFSEALLKR NQDLAPNSAE QASILSLVTK INNVIDNLIV APGTFEVQIE EVRQVGSYKK GTMTTGHNVA DLVVILKILP TLEAVAALGN KVVESLRAQD PSEVLTMLTN ETGFEISSSD ATVKILITTV PPNLRKLDPE LHLDIKVLQS ALAAIRHARW FEENASQSTV KVLIRLLKDL RIRFPGFEPL TPWILDLLGH YAVMNNPTRQ PLALNVAYRR CLQILAAGLF; Positive Samples: MCF7, Raji, A-431, HeLa, Mouse brain, Mouse spleen, Mouse ovary, Mouse thymus, Rat spinal cord; Cellular Location: Cytoplasm, Nucleus, nucleolus
Nuclear factor of activated T-cells is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.
蛋白别名: interleukin enhancer binding factor 2, 45kD; interleukin enhancer binding factor 2, 45kDa; Interleukin enhancer-binding factor 2; Liver regeneration-related protein LRRG031; MGC8391; Nuclear factor of activated T-cells 45 kDa; nuclear factor of activated T-cells, 45-kDa; testis expressed gene 267
基因别名: 6230405A16Rik; Ab1-143; ILF2; NF45; PRO3063; TEG-267; Tex261; Tex267
分子生物学功能: transcription cofactor