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ILK Antibody (711291) in ICC/IF
For immunofluorescence analysis, A549 cells were fixed and permeabilized for detection of endogenous Integrin-linked kinase (ILK) using Anti- Integrin-linked kinase (ILK) Recombinant Rabbit Polyclonal Antibody (Product # 711291, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of Integrin-linked kinase (ILK) protein (green), Panel b) is stained for nuclei (b... View More
产品信息
711291
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
14HCLC
抗原
Protein corresponding to Human ILK (aa 1-300)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2633150
产品详细信息
This antibody is predicted to react with Monkey, Rat, Rabbit and Horse
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 59 kDa serine/threonine-protein kinase; Beta-integrin-linked kinase; epididymis secretory protein Li 28; ILK-1; ILK-2; Integrin linked ILK; integrin-linked kinase; integrin-linked kinase-2; Integrin-linked protein kinase; p59ILK
基因别名: HEL-S-28; ILK; ILK-1; ILK-2; ILK1; ILK2; P59; p59ILK
UniProt ID: (Human) Q13418
Entrez Gene ID: (Human) 3611
branching involved in ureteric bud morphogenesis
positive regulation of cell-matrix adhesion
outflow tract morphogenesis
protein phosphorylation
negative regulation of protein kinase activity
cell cycle arrest
cell-matrix adhesion
integrin-mediated signaling pathway
cell aging
cell proliferation
positive regulation of cell proliferation
negative regulation of cardiac muscle cell apoptotic process
fibroblast migration
negative regulation of smooth muscle cell migration
peptidyl-serine phosphorylation
nerve development
myelination in peripheral nervous system
positive regulation of cell migration
positive regulation of BMP signaling pathway
myelin assembly
regulation of actin cytoskeleton organization
cell junction assembly
substrate adhesion-dependent cell spreading
positive regulation of phosphorylation
extracellular fibril organization
positive regulation of MAP kinase activity
protein kinase B signaling
negative regulation of neuron apoptotic process
establishment or maintenance of epithelial cell apical/basal polarity
positive regulation of myoblast differentiation
positive regulation of osteoblast differentiation
positive regulation of axon extension
positive regulation of transcription, DNA-templated
negative regulation of smooth muscle cell proliferation
neuron projection morphogenesis
positive regulation of dendrite morphogenesis
protein heterooligomerization
positive regulation of protein kinase B signaling
platelet aggregation
positive regulation of canonical Wnt signaling pathway
negative regulation of neural precursor cell proliferation
