Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
ILK Recombinant Rabbit Monoclonal Antibody (6A5)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
图: 1 / 3
ILK Antibody (MA5-49818) in ICC/IF
Immunocytochemistry analysis of MCF7 cells with ILK monoclonal antibody (Product # MA5-49818) at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
产品信息
MA5-49818
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
6A5
抗原
A synthesized peptide derived from human ILK
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: 59 kDa serine/threonine-protein kinase; epididymis secretory protein Li 28; ILK-1; ILK-2; Inactive integrin-linked kinase; integrin binding protein kinase; Integrin linked ILK; integrin-linked kinase; integrin-linked kinase-2; integrin-linked protein kinase; p59ILK; Scaffold protein ILK
基因别名: AA511515; ESTM24; HEL-S-28; ILK; ILK-1; ILK-2; ILK1; ILK2; P59; p59ILK
UniProt ID: (Human) Q13418, (Mouse) O55222
Entrez Gene ID: (Human) 3611, (Mouse) 16202
protein serine/threonine kinase activity
signal transducer activity
integrin binding
protein binding
ATP binding
SH3 domain binding
protein kinase binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
branching involved in ureteric bud morphogenesis
positive regulation of cell-matrix adhesion
outflow tract morphogenesis
protein phosphorylation
negative regulation of protein kinase activity
cell cycle arrest
cell-matrix adhesion
integrin-mediated signaling pathway
cell aging
cell proliferation
positive regulation of cell proliferation
negative regulation of cardiac muscle cell apoptotic process
fibroblast migration
negative regulation of smooth muscle cell migration
peptidyl-serine phosphorylation
nerve development
myelination in peripheral nervous system
positive regulation of cell migration
positive regulation of BMP signaling pathway
myelin assembly
regulation of actin cytoskeleton organization
cell junction assembly
substrate adhesion-dependent cell spreading
positive regulation of phosphorylation
extracellular fibril organization
positive regulation of MAP kinase activity
protein kinase B signaling
negative regulation of neuron apoptotic process
establishment or maintenance of epithelial cell apical/basal polarity
positive regulation of myoblast differentiation
positive regulation of osteoblast differentiation
positive regulation of axon extension
positive regulation of transcription, DNA-templated
negative regulation of smooth muscle cell proliferation
neuron projection morphogenesis
positive regulation of dendrite morphogenesis
protein heterooligomerization
positive regulation of protein kinase B signaling
platelet aggregation
positive regulation of canonical Wnt signaling pathway
negative regulation of neural precursor cell proliferation
regulation of cell growth
regulation of signal transduction
Schwann cell development
phosphorylation
cell projection organization
negative regulation of apoptotic process
positive regulation of MAPK cascade
positive regulation of axonogenesis
