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Proteintech
IMPA1 Polyclonal Antibody
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产品信息
16593-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
IMPA1 Fusion Protein Ag9632 (1-277 aa encoded by BC008381)
偶联物
形式
Liquid
浓度
0.21 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MADPWQECM DYAVTLARQA GEVVCEAIKN EMNVMLKSSP VDLVTATDQK VEKMLISSIK EKYPSHSFIG EESVAAGEKS ILTDNPTWII DPIDGTTNFV HRFPFVAVSI GFAVNKKIEF GVVYSCVEGK MYTARKGKGA FCNGQKLQVS QQEDITKSLL VTELGSSRTP ETVRMVLSNM EKLFCIPVHG IRSVGTAAVN MCLVATGGAD AYYEMGIHCW DVAGAGIIVT EAGGVLMDVT GGPFDLMSRR VIAANNRILA ERIAKEIQVI PLQRDDED (1-277 aa encoded by BC008381)
靶标信息
IMPA1, also known as Myo-inositol monophosphatase 1, is responsible for the procurement of inositol that is required for synthesis of phosphatidylinositol and polyphosphoinositides. IMPA1 exists as a homodimer and has been identified as the pharmacological target for lithium action in the brain. IMPA1 is the principal enzyme of the phosphatidyl inositol signaling pathway, and inhibition of inositol monophosphatase hydrolysis may underlie the anti-manic and anti-depressant actions of Li+. Studies indicate that a variation in the 277 codon coding region of the IMPA1 gene has not been observed in manic-depressive patients, therefore suggesting that polymorphisms or mutations in the noncoding regions of this gene may influence the lithium response in psychiatric patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: D-galactose 1-phosphate phosphatase; IMP 1; IMPase 1; Inositol monophosphatase 1; inositol(myo)-1(or 4)-monophosphatase 1; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; myo-inositol monophosphatase 1; testicular tissue protein Li 94
基因别名: 2610002K09Rik; 2900059K10Rik; AI325909; IMP; IMPA; IMPA1; Impa1-L
UniProt ID: (Human) P29218, (Rat) P97697
Entrez Gene ID: (Human) 3612, (Rat) 83523, (Mouse) 55980
magnesium ion binding
protein binding
inositol monophosphate 1-phosphatase activity
manganese ion binding
lithium ion binding
identical protein binding
protein homodimerization activity
inositol monophosphate 3-phosphatase activity
inositol monophosphate 4-phosphatase activity
inositol monophosphate phosphatase activity
hydrolase activity
metal ion binding
phosphatase
inositol metabolic process
inositol biosynthetic process
phosphatidylinositol biosynthetic process
phosphate-containing compound metabolic process
signal transduction
inositol phosphate metabolic process
phosphatidylinositol phosphorylation
inositol phosphate dephosphorylation
response to lithium ion
