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Rockland
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Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187). Inhibits cell growth and cell proliferation and may play a role in cell cycle control. Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Inhibitor of CDK interacting with cyclin A1; Protein INCA1
基因别名: AI842396; HSD45; INCA1; RGD1306656
UniProt ID: (Human) Q0VD86, (Mouse) Q6PKN7
Entrez Gene ID: (Human) 388324, (Mouse) 103844, (Rat) 360555