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Abnova
INHBB Polyclonal Antibody, MaxPab™
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产品信息
H00003625-D01P
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
INHBB (AAH30029.1, 1 a.a. approximately 407 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MDGLPGRALG AACLLLLAAG WLGPEAWGSP TPPPTPAAQP PPPPPGSPGG SQDTCTSCGG FRRPEELGRV DGDFLEAVKR HILSRLQMRG RPNITHAVPK AAMVTALRKL HAGKVREDGR VEIPHLDGHA SPGADGQERV SEIISFAETD GLASSRVRLY FFISNEGNQN LFVVQASLWL YLKLLPYVLE KGSRRKVRVK VYFQEQGHGD RWNMVEKRVD LKRSGWHTFP LTEAIQALFE RGERRLNLDV QCDSCQELAV VPVFVDPGEE SHRPFVVVQA RLGDSRHRIR KRGLECDGRT NLCCRQQFFI DFRLIGWNDW IIAPTSYYGN YCEGSCPAYL AGVPGSASSF HTAVVNQYRM RGLNPGTVNS CCIPTKLSTM SMLYFDDEYN IVKRDVPNMI VEECGCA
靶标信息
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activin AB beta polypeptide; Activin beta-B chain; Inhibin beta B chain; inhibin, beta B; Inhibin, beta-2
基因别名: INHBB
UniProt ID: (Human) P09529, (Mouse) Q04999
Entrez Gene ID: (Human) 3625, (Mouse) 16324
ovarian follicle development
defense response
cellular response to starvation
response to mechanical stimulus
positive regulation of pathway-restricted SMAD protein phosphorylation
cell differentiation
cellular response to insulin stimulus
activin receptor signaling pathway
growth
regulation of apoptotic process
regulation of MAPK cascade
cellular response to leptin stimulus
fat cell differentiation
negative regulation of insulin secretion
positive regulation of follicle-stimulating hormone secretion
negative regulation of follicle-stimulating hormone secretion
negative regulation of hepatocyte growth factor biosynthetic process
cell development
oocyte development
positive regulation of ovulation
SMAD protein signal transduction
positive regulation of apoptotic signaling pathway
eye development
cellular response to cholesterol
