Invitrogen

INHBB Polyclonal Antibody

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INHBB Antibody in Immunohistochemistry (IHC) — FIGURE 3 Localisation of activin betaA- and betaB-subunits alongside follistatin proteins by immunohistochemistry (IHC) in the FFPE ( n = 90 patients) and fresh ( n = 40 patients) cohorts of malignant colonic tissues according to clinical stages and tumour sidedness (Scale bar = 15 mum). Additionally, the relative protein expression of the targeted molecules in the malignant and normal colonic tissues according to cancer stage and tissue sidedness is shown as boxplots (a = p < 0.05 compared with right-sided normal tissue from early cancer; b = p < 0.05 compared with early stage right-sided colon cancer; c = p < 0.05 compared with left-sided normal tissue from early cancer; d = p < 0.05 compared with early stage left-sided colon cancer; e = p < 0.05 compared with right-sided normal tissue from advanced cancer; f = p < 0.05 compared with advanced stage right-sided colon cancer and g = p < 0.05 compared with left-sided normal tissue from advanced cancer).

产品信息

PA5-50818

应用	建议稀释比	已发表文章
免疫组化 (IHC)	-	查看1篇已发表文章 1篇已发表文章
免疫组化（石蜡） (IHC (P))	1:30-1:150	-

产品规格
种属反应	Human, Mouse, Rat
已发表种属	Not Applicable
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Synthetic peptide of human inhibin, beta B
偶联物	Unconjugated
形式	Liquid
浓度	2.9 mg/mL
纯化类型	Antigen affinity chromatography
保存液	PBS, pH 7.4, with 40% glycerol
内含物	0.05% sodium azide
保存条件	-20°C
RRID	AB_2636270

产品详细信息

The antibody detects endogenous levels of total INHBB protein.

靶标信息

The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Profiling Activins and Follistatin in Colorectal Cancer According to Clinical Stage, Tumour Sidedness and Smad4 Status.

Pathology oncology research : POR

Refaat B,Zekri J,Aslam A,Ahmad J,Baghdadi MA,Meliti A,Idris S,Sultan S,Alardati H,Saimeh HA,Alsaegh A,Alhadrami M,Hamid T,Naeem ME,Elsamany SA

Published figure using INHBB polyclonal antibody (Product # PA5-50818) in Immunohistochemistry

Mon Mar 07 00:00:00 EST 2022

生物信息学

蛋白别名: activin AB beta polypeptide; Activin beta-B chain; activin betaB; Inhibin beta B chain; inhibin beta subunit B; inhibin, beta B; Inhibin, beta-2

基因别名: INHBB

UniProt ID: (Human) P09529, (Mouse) Q04999, (Rat) P17491

Entrez Gene ID: (Human) 3625, (Mouse) 16324, (Rat) 25196

分子生物学功能: growth factor

功能

参与通路

cytokine activity transforming growth factor beta receptor binding hormone activity protein binding growth factor activity protein homodimerization activity host cell surface receptor binding inhibin binding protein heterodimerization activity

INHBB Polyclonal Antibody

产品信息

PA5-50818

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

种属反应

已发表种属

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

RRID

产品详细信息

靶标信息

生物信息学

性能保障

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