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Proteintech
INSIG2 Polyclonal Antibody, CoraLite® Plus 488
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
CL488-24766
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
INSIG2 fusion protein Ag14072
偶联物
CoraLite® Plus 488
CoraLite® Plus 488
CoraLite® Plus 488
激发/发射光谱
493/522 nm
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: TASAVIGLL YPCIDRHLGE PHKFKREWSS VMRCVAVFVG INHASAKVDF DNNIQLSLTL AA
靶标信息
INSIG2 is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ER resident protein; INSIG-2; INSIG-2 membrane protein; INSIG2 membrane protein; insulin induced protein 2; MGC26273; unnamed protein product
基因别名: 2900053I11Rik; C730043J18Rik; INSIG-2
UniProt ID: (Human) Q9Y5U4, (Rat) Q80UA9, (Mouse) Q91WG1
Entrez Gene ID: (Human) 51141, (Rat) 288985, (Mouse) 72999
triglyceride metabolic process
cholesterol biosynthetic process
response to sterol depletion
cholesterol metabolic process
negative regulation of steroid biosynthetic process
sterol biosynthetic process
response to insulin
cellular response to insulin stimulus
SREBP signaling pathway
response to lipid
SREBP-SCAP complex retention in endoplasmic reticulum
inner ear morphogenesis
middle ear morphogenesis
negative regulation of fatty acid biosynthetic process
palate development
cranial suture morphogenesis
response to fatty acid
NLS-bearing protein import into nucleus
positive regulation of cholesterol biosynthetic process
protein maturation
regulation of transcription from RNA polymerase II promoter
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
