Product References
Hyoscyamus albus nortropane alkaloids reduce hyperglycemia and hyperinsulinemia induced in HepG2 cells through the regulation of SIRT1/NF-kB/JNK pathway.
Cell communication and signaling : CCS
Kowalczuk A,Bourebaba N,Kornicka-Garbowska K,Turlej E,Marycz K,Bourebaba L
MA1-10865 was used in Western Blot to demonstrate that calystegines from Hyoscyamus albus provide cytoprotection to the HepG2 cells against insulin/glucose induced insulin resistance and apoptosis due to the regulation of SIRT1/Foxo1/G6PC/mTOR and NF-κB/JNK/TLR4 signaling pathways.
Tue May 25 00:00:00 EDT 2021
Hyoscyamus albus nortropane alkaloids reduce hyperglycemia and hyperinsulinemia induced in HepG2 cells through the regulation of SIRT1/NF-kB/JNK pathway.
Cell communication and signaling : CCS
Kowalczuk A,Bourebaba N,Kornicka-Garbowska K,Turlej E,Marycz K,Bourebaba L
MA1-10865 was used in Western Blot to demonstrate that calystegines from Hyoscyamus albus provide cytoprotection to the HepG2 cells against insulin/glucose induced insulin resistance and apoptosis due to the regulation of SIRT1/Foxo1/G6PC/mTOR and NF-κB/JNK/TLR4 signaling pathways.
Tue May 25 00:00:00 EDT 2021
The beta secretase BACE1 regulates the expression of insulin receptor in the liver.
Nature communications
Meakin PJ,Mezzapesa A,Benabou E,Haas ME,Bonardo B,Grino M,Brunel JM,Desbois-Mouthon C,Biddinger SB,Govers R,Ashford MLJ,Peiretti F
MA1-10865 was used in an ELISA assay to show that plasma levels of cleaved IR reflect IR isoform A expression levels in liver tumors, which prompts us to propose that the measurement of circulating cleaved IR may assist hepatic cancer detection and management.
Tue Apr 03 00:00:00 EDT 2018
A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo.
Cancer research
Burtrum D,Zhu Z,Lu D,Anderson DM,Prewett M,Pereira DS,Bassi R,Abdullah R,Hooper AT,Koo H,Jimenez X,Johnson D,Apblett R,Kussie P,Bohlen P,Witte L,Hicklin DJ,Ludwig DL
MA1-10865 was used in immunoprecipitation to investigate the effectiveness of a humanized monoclonal insulin-like growth factor I receptor antibody against human tumor growth
Mon Dec 15 00:00:00 EST 2003