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Invitrogen
INSR alpha Monoclonal Antibody (83-7)
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INSR alpha Antibody (MA5-13767) in ICC/IF
Immunofluorescence analysis of Insulin receptor was performed using 70% confluent log phase Reh cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with INSR alpha Monoclonal Antibody (83-7) (Product # MA5-13767) at 1:100 dilution in 0.1% BSA, incubated at... View More
产品信息
MA5-13767
应用
建议稀释比
已发表文章
产品规格
已发表种属
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
83-7
抗原
IM-9 lymphocytes followed by IR
偶联物
形式
Liquid
浓度
0.2 mg/mL
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-13767 targets Insulin Receptor alpha in ELISA, ICC/IF, FACS, and IHC (P) applications and shows reactivity with Bovine, Human, Ovine, Porcine, Rat and Rabbit samples.
The MA5-13767 immunogen is iM-9 lymphocytes followed by IR.
靶标信息
Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
