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The antibody detects endogenous levels of total INTS1 protein.
INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit and mediates 3-prime end processing of small nuclear RNAs U1 and U2. RNA polymerase II (Pol II) is an enzyme that is composed of twelve subunits and is responsible for the transcription of protein-coding genes. Transcription initiation requires Pol II-mediated recruitment of transcription machinery to a target promoter, thereby allowing transcription to begin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Int1; Integrator complex subunit 1
基因别名: 1110015K06Rik; INT1; INTS1; KIAA1440; NET28; UNQ1821/PRO3434
UniProt ID: (Human) Q8N201, (Mouse) Q6P4S8
Entrez Gene ID: (Human) 26173, (Mouse) 68510