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Proteintech
IQGAP1 Monoclonal Antibody (2E11A2)
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产品信息
68588-1-IG
应用
建议稀释比
已发表文章
产品规格
种属反应
Rat,
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
2E11A2
抗原
IQGAP1 fusion protein Ag19321
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: QLSSSVTGLT NIEEENCQRY LDELMKLKAQ AHAENNEFIT WNDIQACVDH VNLVVQEEHE RILAIGLINE ALDEGDAQKT LQALQIPAAK LEGVLAEVAQ HYQDTLIRAK REKAQEIQDE SAVLWLDEIQ GGIWQSNKDT QEAQKFALGI FAINEAVESG DVGKTLSALR SPDVGLYGVI PECGETYHSD LAEAKKKKLA VGDNNSKWVK HWVKGGYYYY HNLETQEGGW DEPPNFVQNS MQLSREEIQS SISGVTAAYN REQLWLANEG LITRLQARCR GYLVRQEFRS RMNFLKKQIP AITCIQSQWR GYKQKKAYQD RLAYLRSHKD EVVKIQSLAR MHQARKRYRD
靶标信息
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DISP2; DISPB; p195; Ras GTPase-activating-like protein IQGAP1; RasGAP-like with IQ motifs
基因别名: HUMORFA01; IQGAP1; KIAA0051; p195; SAR1
UniProt ID: (Human) P46940
Entrez Gene ID: (Human) 8826, (Rat) 361598
GTPase inhibitor activity
GTPase activator activity
calcium ion binding
protein binding
calmodulin binding
phosphatidylinositol-3,4,5-trisphosphate binding
protein kinase binding
protein phosphatase binding
protein domain specific binding
protein complex binding
protein serine/threonine kinase activator activity
S100 protein binding
Rac GTPase binding
cadherin binding involved in cell-cell adhesion
Rho GTPase binding
G-protein modulator
protein-binding activity modulator
GTPase-activating protein
regulation of cytokine production
signal transduction
epidermal growth factor receptor signaling pathway
fibroblast growth factor receptor signaling pathway
negative regulation of GTPase activity
negative regulation of dephosphorylation
cellular response to platelet-derived growth factor stimulus
positive regulation of GTPase activity
positive regulation of protein kinase activity
platelet-derived growth factor receptor signaling pathway
cellular response to calcium ion
cellular response to epidermal growth factor stimulus
positive regulation of protein serine/threonine kinase activity
glomerular visceral epithelial cell development
cell-cell adhesion
neuron projection extension
small GTPase mediated signal transduction
cellular response to fibroblast growth factor stimulus
