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产品信息
PA5-50231
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:500-1:2,000 | - |
免疫组化（石蜡） (IHC (P)) |
1:50-1:200 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Full length fusion protein of Human IRAK1BP1 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1.9 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 40% glycerol |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2635684 |
产品详细信息
The antibody detects endogenous levels of total IRAK1BP1 protein.
靶标信息
SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ActA binding protein 3; ActA-binding protein 70; interleukin-1 receptor-associated kinase 1 binding protein 1; Interleukin-1 receptor-associated kinase 1-binding protein 1; IRAK1-binding protein 1; MGC138458; MGC138460; PLK-interacting protein; Signaling molecule that associates with the mouse pelle-like kinase; SIMPL
基因别名: 4921528N06Rik; Aabp3; AI851240; AIP70; IRAK1BP1; SIMPL
UniProt ID: (Human) Q5VVH5, (Mouse) Q9ESJ7
Entrez Gene ID: (Human) 134728, (Mouse) 65099
